IMMUNE RESPONSE TO VARICELLA VACCINATION IN SUBJECTS WITH ATOPIC DERMATITIS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Investigating the immune response to varicella vaccination as a surrogate is expected to yield important information about alterations in the immune response to live virus vaccines in children with AD. Understanding the differences in the immune response in children with and without AD may allow for the development of safer vaccines for smallpox or, alternatively, better treatments for vaccine complications. The central hypothesis of this protocol is that children with AD who are immunized with varicella vaccine will have a decreased CMI to varicella in comparison to nonatopic controls, because of Th2 polarization of their immune system. We postulate the polarization of their immune system toward a Th2 response will result in decreased CM1.