GENETIC AND ENVIRONMENTAL RISK FACTORS IN ATOPIC DERMATITIS

该子项目是利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 中心，不一定是研究者的机构。 特应性皮炎（AD）是儿童期最常见的慢性皮肤病。大多数患有特应性皮炎的儿童会发展成其他特应性疾病，包括食物过敏、过敏性鼻炎和哮喘。 AD的诊断主要基于临床病史和体格检查，病情的改善可以被视为一个年龄。这种疾病的发病率正在增加，据估计影响全世界超过10%的儿童。目前在儿童医院，大约有12，000名AD儿童接受随访，他们大多在很小的时候就出现了。此外，有一个强大的遗传以及环境因素有助于AD的发病机制。 本研究的总体目标包括对在儿童医院随访的AD患者进行表型分析，确定可能与这种疾病相关的已知和新基因的多态性，并调查易患AD的环境和遗传风险因素。最终，从这项研究中收集的数据将使我们能够追求其他假设，并寻找基因-环境相互作用，在AD的发展。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atopic dermatitis (AD) is the most common chronic skin disorder of childhood. The majority of children with atopic dermatitis develop other atopic diseases including food allergy, allergic rhinitis and asthma. The diagnosis of AD is largely based upon clinical history and physical examination and improvement of the condition can be seen as one ages. The incidence of this disorder is increasing and is estimated to affect over 10% of children worldwide. Currently at Children's Hospital, approximately 12,000 children with AD are followed who present mostly at a very young age. Furthermore, there is a strong genetic as well as environmental component contributing to the pathogenesis of AD. The overall goals of this study include phenotyping participants with AD followed at Children's Hospital, identifying polymorphisms in known and novel genes that may be associated with this condition and investigating environmental and genetic risk factors predisposing to the development of AD. Ultimately, the data collected from this study will allow us to pursue other hypotheses, and to look for gene-environment interactions, in the development of AD.