GENETIC AND ENVIRONMENTAL RISK FACTORS IN ATOPIC DERMATITIS

特应性皮炎的遗传和环境风险因素

• 批准号: 7607293
• 负责人: LYNDA C SCHNEIDER
• 金额: $ 1.81万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607293
• 关键词: Affect; Age; Allergic rhinitis; Asthma; Atopic Dermatitis; Child; Childhood; Chronic; Clinical; Computer Retrieval of Information on Scientific Projects Database; Condition; Data; Development; Diagnosis; Disease; Environmental Risk Factor; Food Hypersensitivity; Funding; Genes; Genetic; Genetic Polymorphism; Goals; Grant; Incidence; Institution; Participant; Pathogenesis; Pediatric Hospitals; Phenotype; Physical Examination; Recording of previous events; Research; Research Personnel; Resources; Source; United States National Institutes of Health; base; gene environment interaction; genetic risk factor; novel; skin disorder

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Atopic dermatitis (AD) is the most common chronic skin disorder of childhood. The majority of children with atopic dermatitis develop other atopic diseases including food allergy, allergic rhinitis and asthma. The diagnosis of AD is largely based upon clinical history and physical examination and improvement of the condition can be seen as one ages. The incidence of this disorder is increasing and is estimated to affect over 10% of children worldwide. Currently at Children's Hospital, approximately 12,000 children with AD are followed who present mostly at a very young age. Furthermore, there is a strong genetic as well as environmental component contributing to the pathogenesis of AD. The overall goals of this study include phenotyping participants with AD followed at Children's Hospital, identifying polymorphisms in known and novel genes that may be associated with this condition and investigating environmental and genetic risk factors predisposing to the development of AD. Ultimately, the data collected from this study will allow us to pursue other hypotheses, and to look for gene-environment interactions, in the development of AD.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 特应性皮炎(AD)是儿童最常见的慢性皮肤病。大多数患有特应性皮炎的儿童会患上其他特应性疾病，包括食物过敏、过敏性鼻炎和哮喘。AD的诊断在很大程度上是基于临床病史和体格检查，病情的改善可以视为一个时期。这种疾病的发病率正在增加，据估计，全世界有超过10%的儿童受到影响。目前在儿童医院，约有12,000名患有阿尔茨海默病的儿童被跟踪，他们大多很小就出现了。此外，阿尔茨海默病的发病与遗传和环境因素密切相关。 这项研究的总体目标包括对儿童医院的AD患者进行表型分型，识别可能与此疾病相关的已知和新基因的多态性，并调查易患AD的环境和遗传风险因素。最终，从这项研究中收集的数据将使我们能够在阿尔茨海默病的发展过程中寻求其他假设，并寻找基因-环境相互作用。