GENETICS OF ATOPIC DERMATITIS - ECZEMA HERPETICUM (ADEH) STUDY

特应性皮炎的遗传学 - 疱疹性湿疹 (ADEH) 研究

• 批准号: 7607301
• 负责人: LYNDA C SCHNEIDER
• 金额: $ 0.58万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607301
• 关键词: Atopic Dermatitis; Candidate Disease Gene; Computer Retrieval of Information on Scientific Projects Database; Development; Eczema Herpeticum; Eczema Vaccinatum; Funding; Gene Expression Profiling; Genetic; Genetic Determinism; Genetic Variation; Genomics; Genotype; Grant; Immune response; Infection; Institution; Life; Molluscum contagiosum virus; Numbers; Pathway interactions; Personal Satisfaction; Phenotype; Recording of previous events; Research; Research Personnel; Resources; Sampling; Simplexvirus; Skin; Source; Technology; Testing; United States National Institutes of Health; Variant; Virus; Virus Diseases; base; design; novel; trait

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although virtually nothing is known about the genetic basis of atopic dermatitis (AD) with a history of eczema herpeticum (EH) the evidence for a genetic basis in AD is well established, and a limited number of studies have identified allelic variants in candidate genes associated with AD. This project is designed to test for genetic determinants in this sub-phenotype of AD: ADEH+. We have chosen to focus upon EH because it is felt to represent a reasonable, "real-life" surrogate for eczema vaccinatum (EV). Not all subjects with AD develop EH. It is unlikely that this is explained by differences in herpes simplex virus (HSV) exposure. We hypothesize that the variation in host response to herpes infection may be a heritable trait. The objective of this study is to use new genomic technologies using high-throughput genotyping and guided by gene expression profiling studies in skin samples infected with 2 different viruses (HSV and molluscum contagiosum virus [MCV]) to provide significant and novel information on the pathways responsible for the development of EH and possibly other relevant viral infections seen more commonly in AD subjects (e.g., EV and MCV).

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