GENETICS OF ATOPIC DERMATITIS - ECZEMA HERPETICUM (ADEH) STUDY

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，但不一定是研究者所在的机构。 虽然几乎没有什么是已知的遗传基础的特应性皮炎（AD）与疱疹性湿疹（EH）的历史，AD的遗传基础的证据是很好的建立，和数量有限的研究已经确定了等位基因变异的候选基因与AD。该项目旨在检测AD：ADEH+亚表型中的遗传决定因素。我们选择关注EH，因为它被认为是疫苗性湿疹（EV）的合理的“现实生活”替代品。并非所有AD受试者都发生EH。这不太可能通过单纯疱疹病毒（HSV）暴露的差异来解释。我们推测宿主对疱疹感染反应的变异可能是一种遗传性状。本研究的目的是使用新的基因组技术，使用高通量基因分型，并在感染2种不同病毒（HSV和传染性软疣病毒[MCV]）的皮肤样本中进行基因表达谱研究，以提供有关导致EH发展的途径的重要和新的信息，以及可能在AD受试者中更常见的其他相关病毒感染（例如，EV和MCV）。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although virtually nothing is known about the genetic basis of atopic dermatitis (AD) with a history of eczema herpeticum (EH) the evidence for a genetic basis in AD is well established, and a limited number of studies have identified allelic variants in candidate genes associated with AD. This project is designed to test for genetic determinants in this sub-phenotype of AD: ADEH+. We have chosen to focus upon EH because it is felt to represent a reasonable, "real-life" surrogate for eczema vaccinatum (EV). Not all subjects with AD develop EH. It is unlikely that this is explained by differences in herpes simplex virus (HSV) exposure. We hypothesize that the variation in host response to herpes infection may be a heritable trait. The objective of this study is to use new genomic technologies using high-throughput genotyping and guided by gene expression profiling studies in skin samples infected with 2 different viruses (HSV and molluscum contagiosum virus [MCV]) to provide significant and novel information on the pathways responsible for the development of EH and possibly other relevant viral infections seen more commonly in AD subjects (e.g., EV and MCV).