BRAIN IMAGING INVESTIGATIONS OF UNIPOLAR DEPRESSED PATIENTS

单极抑郁症患者的脑成像研究

• 批准号: 7627521
• 负责人: JAIR C SOARES
• 金额: $ 4.61万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7627521
• 关键词: Age; Basal Ganglia; Biochemical; Blood Platelets; Blood specimen; Brain; Brain imaging; Brain region; Brain scan; Computer Retrieval of Information on Scientific Projects Database; Condition; Densitometry; Depressed mood; Development; Educational Status; Functional disorder; Funding; Future; Grant; Inositol; Institution; Investigation; Lasers; Medial; Membrane; Mental Depression; Mood Disorders; Pathway interactions; Patients; Phosphatidylinositols; Population; Protons; Race; Research; Research Personnel; Resources; Scanning; Source; Suicide attempt; Symptoms; Temporal Lobe; Thin Layer Chromatography; Time; United States National Institutes of Health; clinically relevant; frontal lobe; in vivo; mood regulation; morphometry; myoinositol; neurochemistry; sex; suicidal behavior; suicidal risk; two-dimensional

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. OBJECTIVE: This study will examine the existence of particular in vivo neurochemical and morphometric brain abnormalities in unipolar mood disorder subjects, and their potential involvement in the pathophysiology of this illness. We will also examine potential in vivo brain correlates of prior suicidal behavior in this patient population. RESEARCH PLAN: We will investigate regional brain myo-inositol and platelet membrane phosphoinositide levels in 30 unmedicated unipolar patients (15 depressed and 15 in the remitted state) and 30 age, sex, educational level, and race-matched healthy controls. In addition to that, we will examine brain morphometry of key brain regions involved in mood regulation, to attempt to determine their relationship with illness symptoms. We will also examine brain correlates of suicide behavior by comparing patients with prior suicide attempts and the ones without such attempts. METHODS: All subjects undergo a 1.5T proton MIR/MRS brain scan, which allows the quantitation of myoinositol in 8cc brain voxels located in the frontal cortex, medial temporal lobe, and basal ganglia. At the same time, subjects provide a blood sample for platelet determination of membrane phosphoinositides, which is done with two-dimensional thin layer chromatography, followed by scanning laser densitometry. This research holds substantial promise to contribute to a better understanding of the biochemical brain dysfunction underlying mood disorders, and ultimately guide future efforts towards the development of new treatments for these conditions. CLINICAL RELEVANCE: This study will allow examination of involvement of abnormalities in the phosphoinositol (PI) pathway in pathophysiology of depression and mood disorders. It will also allow examination of anatomical involvement of specific brain regions participating in mood regulation in the pathophysiology of mood disorders. It could also possibly aid in development of new ways to identify depressed unipolar patients at high risk for suicide.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目的：本研究将检查单相情感障碍受试者体内特定神经化学和形态测量脑异常的存在，以及它们在该疾病的病理生理学中的潜在参与。 我们还将检查该患者群体先前自杀行为的潜在体内大脑相关性。 研究计划：我们将调查 30 名未接受药物治疗的单相患者（15 名抑郁症患者和 15 名缓解状态患者）和 30 名年龄、性别、教育水平和种族匹配的健康对照者的区域脑肌醇和血小板膜磷酸肌醇水平。 除此之外，我们还将检查与情绪调节有关的关键大脑区域的大脑形态测量，以试图确定它们与疾病症状的关系。 我们还将通过比较有过自杀企图的患者和没有自杀企图的患者来检查自杀行为的大脑相关性。 方法：所有受试者均接受 1.5T 质子 MIR/MRS 脑部扫描，可对位于额叶皮层、内侧颞叶和基底神经节的 8cc 脑体素中的肌醇进行定量。 同时，受试者提供血液样本用于血小板膜磷酸肌醇的测定，该测定通过二维薄层色谱法完成，然后进行扫描激光密度测定。 这项研究有望有助于更好地理解情绪障碍背后的生化脑功能障碍，并最终指导未来开发针对这些疾病的新疗法。 临床相关性：这项研究将允许检查磷酸肌醇 (PI) 途径异常在抑郁症和情绪障碍病理生理学中的参与情况。 它还将允许检查参与情绪障碍病理生理学中情绪调节的特定大脑区域的解剖学参与。 它还可能有助于开发新方法来识别自杀高风险的抑郁单相患者。