IN VIVO BRAIN MECHANISMS ACROSS THE BIPOLAR SPECTRUM

跨双极谱的体内大脑机制

• 批准号: 8363447
• 负责人: JAIR C SOARES
• 金额: $ 0.51万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8363447
• 关键词: Anxiety Disorders; Bipolar Disorder; Brain; Brain imaging; Brain region; Clinical; Clinical Research; Data; Development; Development Plans; Disease; Etiology; Fostering; Functional disorder; Funding; Generations; Grant; Health Sciences; Healthcare Systems; Link; Magnetic Resonance Imaging; Mentors; Mid-Career Clinical Scientist Award (K24); Modeling; Mood Disorders; National Center for Research Resources; Patients; Pilot Projects; Positioning Attribute; Principal Investigator; Psychiatry; Radiology Specialty; Research; Research Activity; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Source; South Texas; Spectrum Analysis; Staging; Symptoms; Testing; Texas; Time; United States National Institutes of Health; Universities; Veterans; career; career development; computational anatomy; cost; in vivo; neurobiological mechanism; patient oriented research; professor; programs

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The candidate is an Associate Professor of Psychiatry and Radiology and Krus Endowed Chair in Psychiatry at the University of Texas Health Science Center in San Antonio (UTHSCSA), where he also holds the position of Chief, Division of Mood and Anxiety Disorders. He also is Chief, VA Psychiatry Research, South Texas Veterans Health Care System. Dr. Soares has led his independent research lab, which focuses on brain imaging studies on mood disorders, and has mentored several trainees and young investigators at various levels. At the mid-career stage, he is proposing to continue to develop his research and academic activities, and dedicate a substantial amount of time to mentoring young investigators on patient-oriented research in Psychiatry, in particular in the fields of mood disorders and brain imaging. These activities are very inter-linked to the program at the General Clinical Research Center (GCRC) at UTHSCSA. The career development plan proposed here will utilize the mid-career mechanism of the NCRR K24 award to foster Dr. Soares' academic career and allow substantial time for him to continue to dedicate to research activities and mentoring on patient-oriented research. It will focus on studies of the neurobiological mechanisms implicated in causation of bipolar disorder. The K24 application involves a developmental (pilot) research project where 30 bipolar type I and 30 bipolar type II patients will be studied with magnetic resonance imaging (MR!) and spectroscopy (MRS), to begin to examine neurobiological mechanisms implicated across,the bipolar spectrum. Our pilot study will elicit preliminary data towards an R01 application that will further test the hypothesis that brain abnormalities in fronto-limbic brain regions in bipolar spectrum patients are distributed along a continuum, which reflects the spectrum of clinical symptoms seen in these patients. These activities are likely to result in substantial contributions to a better understanding of the pathophysiology of bipolar spectrum disorders. The proposed K24 plan will give the candidate the needed time to continue to develop his independent research lab and to focus on mentoring the new generation of young investigators on patient-oriented research in the field of Psychiatry.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 该候选人是圣安东尼奥德克萨斯大学健康科学中心 (UTHSCSA) 的精神病学和放射学副教授以及 Krus 精神病学主席，他还担任该中心情绪和焦虑障碍科主任。他还是南德克萨斯退伍军人医疗保健系统 VA 精神病学研究部的负责人。苏亚雷斯博士领导了他的独立研究实验室，该实验室专注于情绪障碍的脑成像研究，并指导了几名不同级别的学员和年轻研究人员。在职业生涯中期，他建议继续发展他的研究和学术活动，并投入大量时间指导年轻研究人员进行以患者为导向的精神病学研究，特别是在情绪障碍和脑成像领域。这些活动与 UTHSCSA 普通临床研究中心 (GCRC) 的项目密切相关。这里提出的职业发展计划将利用 NCRR K24 奖项的职业中期机制来促进 Soares 博士的学术生涯，并为他提供大量时间继续致力于研究活动和指导以患者为导向的研究。它将重点研究与双相情感障碍病因有关的神经生物学机制。 K24 应用涉及一个发展（试点）研究项目，其中将使用磁共振成像 (MR!) 和光谱学 (MRS) 对 30 名双相 I 型和 30 名双相 II 型患者进行研究，以开始检查双相频谱中涉及的神经生物学机制。我们的试点研究将得出 R01 应用的初步数据，进一步检验双相情感障碍患者额边缘脑区域的大脑异常沿着连续体分布的假设，这反映了这些患者所见的临床症状的范围。这些活动可能会对更好地了解双相谱系障碍的病理生理学做出重大贡献。拟议的 K24 计划将为候选人提供所需的时间来继续发展他的独立研究实验室，并专注于指导新一代年轻研究人员进行精神病学领域以患者为导向的研究。