IN VIVO BRAIN MECHANISMS ACROSS THE BIPOLAR SPECTRUM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 该候选人是精神病学和放射学副教授，也是德克萨斯大学圣安东尼奥健康科学中心（UTHSCSA）精神病学的Krus捐赠主席，在那里他还担任情绪和焦虑障碍部门的负责人。他还担任南德克萨斯州退伍军人医疗保健系统退伍军人精神病学研究主任。Soares博士领导了他的独立研究实验室，该实验室专注于情绪障碍的脑成像研究，并指导了不同级别的几名学员和年轻研究人员。在职业生涯中期，他建议继续发展他的研究和学术活动，并投入大量的时间来指导年轻的研究人员在精神病学以病人为导向的研究，特别是在情绪障碍和脑成像领域。这些活动与UTHSCSA的综合临床研究中心（GCRC）的项目密切相关。这里提出的职业发展计划将利用NCRR K24奖的职业生涯中期机制来促进苏亚雷斯博士的学术生涯，并让他有足够的时间继续致力于研究活动和指导以患者为导向的研究。它将集中在双相情感障碍的病因所涉及的神经生物学机制的研究。K24应用涉及一个开发（试点）研究项目，其中将使用磁共振成像（MR！）对30名I型双极和30名II型双极患者进行研究。和波谱学（MRS），以开始检查涉及双极频谱的神经生物学机制。我们的初步研究将引出R 01应用的初步数据，该数据将进一步检验双相谱系患者额边缘脑区域的脑异常沿沿着连续分布的假设，该连续分布反映了这些患者中观察到的临床症状谱。这些活动可能会导致实质性的贡献，更好地了解双相谱系障碍的病理生理学。拟议的K24计划将为候选人提供所需的时间，继续发展他的独立研究实验室，并专注于指导新一代年轻研究人员在精神病学领域进行以患者为导向的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The candidate is an Associate Professor of Psychiatry and Radiology and Krus Endowed Chair in Psychiatry at the University of Texas Health Science Center in San Antonio (UTHSCSA), where he also holds the position of Chief, Division of Mood and Anxiety Disorders. He also is Chief, VA Psychiatry Research, South Texas Veterans Health Care System. Dr. Soares has led his independent research lab, which focuses on brain imaging studies on mood disorders, and has mentored several trainees and young investigators at various levels. At the mid-career stage, he is proposing to continue to develop his research and academic activities, and dedicate a substantial amount of time to mentoring young investigators on patient-oriented research in Psychiatry, in particular in the fields of mood disorders and brain imaging. These activities are very inter-linked to the program at the General Clinical Research Center (GCRC) at UTHSCSA. The career development plan proposed here will utilize the mid-career mechanism of the NCRR K24 award to foster Dr. Soares' academic career and allow substantial time for him to continue to dedicate to research activities and mentoring on patient-oriented research. It will focus on studies of the neurobiological mechanisms implicated in causation of bipolar disorder. The K24 application involves a developmental (pilot) research project where 30 bipolar type I and 30 bipolar type II patients will be studied with magnetic resonance imaging (MR!) and spectroscopy (MRS), to begin to examine neurobiological mechanisms implicated across,the bipolar spectrum. Our pilot study will elicit preliminary data towards an R01 application that will further test the hypothesis that brain abnormalities in fronto-limbic brain regions in bipolar spectrum patients are distributed along a continuum, which reflects the spectrum of clinical symptoms seen in these patients. These activities are likely to result in substantial contributions to a better understanding of the pathophysiology of bipolar spectrum disorders. The proposed K24 plan will give the candidate the needed time to continue to develop his independent research lab and to focus on mentoring the new generation of young investigators on patient-oriented research in the field of Psychiatry.