AGE, SEX & BALANCE BTW CARDIAC OUTPUT & MUSCLE BLOOD FLOW IN EXERCISING HUMANS

年龄、性别

• 批准号: 7625839
• 负责人: Samuel James Ridout
• 金额: $ 0.04万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-04-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7625839
• 关键词: Address; Age; Blood flow; Cardiac; Cardiac Output; Computer Retrieval of Information on Scientific Projects Database; Equilibrium; Exercise; Funding; Grant; Heart; Human; Infusion Pumps; Institution; Leg; Limb structure; Measures; Muscle; Perfusion; Physiology; Protocols documentation; Pump; Relative (related person); Research; Research Personnel; Resources; Sample Size; Skeletal Muscle; Source; United States National Institutes of Health; Woman; Work; age effect; aged; men; older women; response; sedentary; sex

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Older sedentary men preserve blood flow to the working muscles by directing a higher percentage of their cardiac output to the working limbs and having an exaggerated pressor response relative to young men. In contrast, aged women cannot maintain leg blood flow during upright cycling exercise and attempt to optimize leg blood flow by an even further exaggerated pressor response during upright exercise. This protocol will address this issue to determine the effect of aging on the interplay between exercising muscle demand for perfusion and the pumping capacity of the heart in aged humans. Additionally, the subject groups studied will consist of sufficient sample sizes to assess ageXsex interactions in each of the variables measured, a methodological perspective rarely taken in human physiology. Hypothesis: The peak perfusion measured during maximal single leg extension exercise in aged women and men, when extrapolated to the entire limb muscle mass, will exceed the cardiac pumping capacity by a greater degree in the older women and men than younger sex-matched subjects indicating a greater need to vasoconstrict working skeletal muscle in aged women and men.

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 与年轻人相比，久坐不动的老年男性通过将更高比例的心输出量引导到工作肢体，并具有夸大的升压反应，来保护流向工作肌肉的血液。相比之下，老年女性无法在直立自行车运动中保持腿部血液流动，并试图通过直立运动中进一步夸大的升压反应来优化腿部血液流动。该方案将解决这一问题，以确定衰老对老年人锻炼肌肉的灌流需求和心脏泵血能力之间的相互作用的影响。此外，研究对象组将由足够的样本大小组成，以评估每个测量变量中的年龄性别交互作用，这是人类生理学中很少采用的方法论观点。 假设：老年女性和男性在最大单腿伸展运动中测得的峰值血流灌注，当外推到整个肢体肌肉质量时，老年女性和男性将比年轻性别匹配的受试者更大程度地超过心脏泵送能力，这表明老年女性和男性更需要工作骨骼肌的血管收缩。