Understanding healthy ageing heart flow patterns, hemodynamics and energetics using experimental models and age/sex-based three-dimensional blood flow velocity nomograms

纵观人类历史，心脏一直是智力上的挑战。自从列奥纳多对跨瓣膜漩涡形成的描述和他关于血管壁层具有旋转运动的有趣概念以来，图像技术的进步可以帮助我们更好地了解正常的心脏血流动力学。近年来，越来越多的证据表明，男性和女性在心脏老化方面存在差异。尤其是女性的心脏血流动力学，需要更好地理解。在过去的三年里，我为一个专门的4D流MRI项目提供了基础设施。后者提供了整个心脏空间覆盖整个心脏周期允许血流动力学的综合评估。在我的博士后研究期间，我开发了技术和方法来评估年龄和性别的血流动力学差异使用4D血流MRI。后者激发了本课程的目标。该计划承担的挑战是扩大我们对健康衰老的人类心脏的理解，使用基于年龄/性别的图来建立基于年龄/性别的实验模型（目标1），后者将用于评估血流动力学性能的动态范围（目标2），并通过评估（目标3）三维血流模式，血流动力学，能量生物标志物和漩涡形成将为描述由于衰老和生物性别差异而导致的复杂血流动力学变化制定策略。该计划的目标将为研究健康衰老心脏的血流动力学变化提供一个新颖而独特的机会。后者建立了心脏建模的新范式。这一创新项目将为培养高素质人才和未来专注于图像引导建模和心血管血流动力学的学术领袖提供一个特殊的环境。这种环境将通过我们的多学科科学团队与我们建立的加拿大和国际行业合作伙伴之间的密切互动来促进。

The heart has presented an intellectual challenge throughout mankind history. Since Leonardo's description of trans-valvular vortex formation and his interesting notion of vessel wall layer with eddying motion, the advances in image technology can help us to better understand normal heart hemodynamics. In recent years more evidence supporting the differences between men and women aging heart has come into light. Women's heart hemodynamics, particularly, need to be better understood. In the last three years, I seeded the infrastructure for a dedicated program in 4D flow MRI. The latter provides a whole heart spatial coverage throughout the cardiac cycle allowing for a comprehensive assessment of blood flow hemodynamics. During my postdoctoral fellowships, I developed techniques and methods to assess age and sex hemodynamic differences using 4D flow MRI. The latter motivates the aims of this program. The proposed program undertakes the challenge of expanding our understanding of the healthy ageing human heart using age/sex-based nomograms to build age/sex-based experimental models (Aim 1), the latter will serve to assess the dynamic range of hemodynamic performance (Aim 2), and by assessing (Aim 3) three-dimensional blood flow patterns, hemodynamics, energetic biomarkers and vortex formation will develop strategies for characterizing complex hemodynamics changes due to ageing and biological sex differences. The proposed aims of this program will provide a novel and unique opportunity to investigate the hemodynamic alterations of the healthy aging heart. The latter establishes a novel paradigm for heart modelling. This innovative program will provide an exceptional environment for the training of highly qualified personnel and future academic leaders focused on image-guided modelling and cardiovascular hemodynamics. This environment will be fostered by close interaction between our multidisciplinary scientific team and our established Canadian and international industry partners.