HYPERSPECTRAL IMAGING TO ASSESS AND PREDICT DIABETIC FOOT ULCERS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 足病并发症严重影响糖尿病患者的生活。一种量化的方法来评估治疗的效果，或者更好的方法，来确定危险组织并防止最初的溃疡形成，将是非常有益的。这项研究是由美国国立卫生研究院资助的HyperMed公司多中心研究的一部分，其长期目标是通过开发医学高光谱成像(MHSI)来减少足部溃疡的频率。基于MHSI相机的系统(由HyperMed，Inc.制造)在这项研究中被用来识别有溃疡风险的组织，评估溃疡的愈合能力和监测治疗效果。MHSI为图像提供了每个像素固有的光谱数据，反映了各种化学物种的存在和浓度。 这项研究的具体目的是：1)评估10名有明显足部溃疡的1型和12名2型糖尿病患者的愈合或进展；2)在一项旨在预测溃疡的纵向研究中，研究30名1型和40名2型糖尿病患者的足部溃疡高危状态；3)验证使用临床结果测量进一步发展MHSI的价值，并将MHSI与现有方法(TcPO2)进行比较，以确定MHSI在临床足部护理中的优势和局限性。MHSI可能是一种具有成本效益的、易于使用的、基于相机的交钥匙工具，它以简单易懂的图像传递代谢信息。它将对糖尿病患者的生活质量产生积极影响，影响发病率和死亡率，并降低整体医疗成本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Foot disease complications seriously impact lives of people with diabetes. A quantitative method to evaluate efficacy of therapy, or better, to define tissue at risk & prevent initial ulcer formation would be highly beneficial. This study, part of a multicenter study by HyperMed Inc. (STTR, funded by the NIH) has a long-term objective to reduce frequency of foot ulceration by developing Medical HyperSpectral Imaging (MHSI). The MHSI camera-based system (manufactured by HyperMed, Inc.) is used in this study to identify tissue at risk for ulceration, evaluate the healing capability of an ulcer & monitor treatment efficacy. MHSI provides an image with spectral data inherent in each pixel which reflects the presence & concentration of various chemical species. Specific aims of this study are to: 1) assess healing or progression in 10 type 1 and 12 type 2 diabetic patients with manifest foot ulcers, 2) study 30 type 1 and 40 type 2 diabetic patients at high risk for foot ulceration in a longitudinal study aimed at predicting ulceration, 3) validate merit in further developing MHSI using clinical outcome measures & comparing MHSI with existing methods (TcPO2) to determine advantages & limitations of MHSI in clinical foot care. MHSI is potentially a cost effective, easy to use, turn-key camera-based tool, which delivers metabolic information in a simple to interpret image. It will positively impact the quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs.