HYPERSPECTRAL IMAGING TO ASSESS AND PREDICT DIABETIC FOOT ULCERS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 足部疾病并发症严重影响糖尿病患者的生活。评估治疗效果的定量方法，或更好地，以确定组织的风险和防止初始溃疡形成将是非常有益的。本研究是HyperMed Inc.多中心研究的一部分。(STTR由NIH资助）的长期目标是通过开发医学超光谱成像（MHSI）来降低足部溃疡的频率。 基于MHSI相机的系统（由HyperMed，Inc.在本研究中用于识别有溃疡风险的组织，评估溃疡的愈合能力并监测治疗效果。 MHSI提供了一个图像，每个像素中固有的光谱数据反映了各种化学物质的存在和浓度。 这项研究的具体目标是：1）评估10名具有明显足部溃疡的1型和12名2型糖尿病患者的愈合或进展，2）在旨在预测溃疡的纵向研究中研究30名具有足部溃疡高风险的1型和40名2型糖尿病患者，3）使用临床结果测量验证进一步开发MHSI的优点，并将MHSI与现有方法（TcPO 2）进行比较，以确定MHSI在临床足部护理中的优点和局限性。 MHSI可能是一种具有成本效益，易于使用，基于相机的交钥匙工具，它可以在简单的图像中提供代谢信息。它将对糖尿病患者的生活质量产生积极影响，影响发病率和死亡率，降低整体医疗成本。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Foot disease complications seriously impact lives of people with diabetes. A quantitative method to evaluate efficacy of therapy, or better, to define tissue at risk & prevent initial ulcer formation would be highly beneficial. This study, part of a multicenter study by HyperMed Inc. (STTR, funded by the NIH) has a long-term objective to reduce frequency of foot ulceration by developing Medical HyperSpectral Imaging (MHSI). The MHSI camera-based system (manufactured by HyperMed, Inc.) is used in this study to identify tissue at risk for ulceration, evaluate the healing capability of an ulcer & monitor treatment efficacy. MHSI provides an image with spectral data inherent in each pixel which reflects the presence & concentration of various chemical species. Specific aims of this study are to: 1) assess healing or progression in 10 type 1 and 12 type 2 diabetic patients with manifest foot ulcers, 2) study 30 type 1 and 40 type 2 diabetic patients at high risk for foot ulceration in a longitudinal study aimed at predicting ulceration, 3) validate merit in further developing MHSI using clinical outcome measures & comparing MHSI with existing methods (TcPO2) to determine advantages & limitations of MHSI in clinical foot care. MHSI is potentially a cost effective, easy to use, turn-key camera-based tool, which delivers metabolic information in a simple to interpret image. It will positively impact the quality of life of people with diabetes, impacting morbidity & mortality & lowering overall healthcare costs.