COBRE: UD: ADMININSTRATION CORE: OSTEOARTHRITIS: PREVENTION AND TREATMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们建议在特拉华大学建立一个生物医学研究中心，专注于骨关节炎的预防和治疗。这项提案涉及四个研究项目，每个项目由一名初级教员领导，并由资深教员指导。 在第一个项目中，诺沃特尼博士将使用动物模型来检查软骨组织的机械性能。在第二个项目中，马纳尔博士建议使用一个基于核磁共振和肌电数据的生物力学模型，在进行日常生活活动时检查膝关节的运动学和动力学。在我们的第三个项目中，Royer博士建议检查膝盖骨关节炎患者鞋内楔形物对静态对齐测量的影响。此外，还将检查这种治疗的长期效果。在第四个项目中，鲁道夫博士将研究膝内翻(“弓腿畸形”)，这通常会导致膝关节内侧间隙的关节炎。本研究的目的是研究截骨楔形截骨联合骨痂牵张矫正膝内翻手术前后运动和肌肉活动的差异。 除了这四个项目，核心由两个共享设施组成：一个步态分析实验室和一个姿势和运动生物力学实验室。行政核心还为小型试点项目提供资金。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We propose to establish a center of biomedical research excellence at the University of Delaware that will focus on the prevention and treatment of osteoarthritis. This proposal involves four research projects, each lead by a junior faculty member who will be mentored by senior faculty. In project one, Dr. Novotny will use an animal model to examine the mechanical properties of cartilage tissue. In the second project, Dr. Manal proposes to use a biomechanical model based on MRI and electromyographic data to examine knee kinematics and kinetics while performing activities of daily living. In our third project, Dr. Royer proposes to examine the examine the effects of in-shoe wedges in patients with knee OA on static alignment measures. In addition, the long-term effect of this treatment will also be examined. In the fourth project, Dr. Rudolph will study genu varum ("bowleggedness"), which often leads to arthritis on the medial compartment of the knee. The purpose of this study is to characterize the differences in movement and muscle activity before and after an opening wedge osteotomy with callus distraction to correct genu varum. In addition to the four projects, the core consists of two shared facilities: a Gait Analysis Lab and a Posture and Movement Biomechanics Lab. The Administrative core also funds small pilot projects.