COBRE: UD: ADMININSTRATION CORE: OSTEOARTHRITIS: PREVENTION AND TREATMENT

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在这笔Cobre II赠款中，我们的目标是培养骨关节炎(OA)领域的多学科研究人员，从实验室到临床，特别关注指导女性科学与工程(WISE)。在这项提案中，五个项目中的每个项目都由一名女教职员工领导。理科，尤其是工程学的女性教员比例偏低。在特拉华大学，女性占理科教员的17%，占工程学教员的10%。特拉华州在这方面并不是独一无二的。全国平均水平显示出类似的趋势(Nelson，2005)。因此，我们的目标是为指导和促进在关节炎研究领域工作的女性教员提供一个论坛。 这笔Cobre II奖助金和Cobre I奖助金一样，是通过特拉华大学的生物医学工程研究中心(CBER)管理的。CBER成立于20世纪90年代初的S，为不同部门的研究人员提供了一个论坛，利用生物医学工程工具共同开展与转化医学相关的多学科项目。无一例外，所有通过该中心的研究资助(主要是R01)都有来自至少两所大学的教师共同参与多学科项目，将基础研究和临床治疗结合在一起。 这笔Cobre II赠款的科学目标是建立基础设施和专门知识基础，以解决骨性关节炎的机制及其预防和治疗问题。本中心采用的方法的独特性是从组织力学、生物力学、物理治疗和临床干预的综合角度对骨关节炎进行检查。我们最初授予的Cobre I已经为此奠定了基础。在我们提议的工作中，我们将建立在CBER独特的组织和本申请中描述的协作项目的基础上。 如上所述，除了该中心的总体研究目标提供的整合外，我们的目标是建立一个核心设施，指导科学和工程领域的妇女。我们还计划继续并扩大我们在生物医学成像领域的仪器核心。多个项目受益于该中心提供的核心设施。我们还鼓励大学中没有直接参与该中心的其他教职员工利用这些核心，并将提供指导、技术人员和培训，以使这些好处更容易获得。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this COBRE II grant we aim to develop multidisciplinary researchers in the field of osteoarthritis (OA), from the lab bench to the clinic, with a unique focus on mentoring Women In Science and Engineering (WISE). In this proposal, each of the five projects is lead by a women faculty member. Women faculty in science, and especially engineering, are under-represented. At the University of Delaware, women make up 17% of the faculty of science and 10% of the faculty in engineering. Delaware is not unique in this regard. National averages show similar trends (Nelson, 2005). Thus, our aim is to provide a forum for mentoring and promoting women faculty working in the field of arthritis research. This COBRE II grant, as is COBRE I grant, is administered through our Center for Biomedical Engineering Research (CBER) at the University of Delaware. CBER has been in existence since the early 1990's and provides a forum for researchers in different departments to work together on mulitidisciplinary projects related to translational medicine using biomedical engineering tools. Without exception, all of the research grants through the center (which are mostly R01s) have faculty from at least two colleges working together on multidisciplinary projects that tie together both basic research and clinical treatment. The scientific goal of this COBRE II grant is to create the infrastructure and expertise base to address the mechanisms of OA, as well as its prevention and treatment. The uniqueness of the approach to be employed by our center will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, physical therapy and clinical intervention. A foundation for this has been laid by our initial COBRE I grant. In our proposed work, we will build upon the distinctive organization of CBER and the collaborative projects described in this application. In addition to the integration provided by the overarching research aims of the Center, as mentioned above, we aim to establish a core facility for mentoring women in science and engineering. We also aim to continue and expand our instrumentation core in the area of biomedical imaging. Multiple projects benefit from the core facilities provided by the Center. We also encourage other faculty at the University that are not directly involved in the Center to make use of these cores, and will provide mentoring, technical staff and training to make such benefits more accessible.