COBRE: UD: ADMININSTRATION CORE: OSTEOARTHRITIS: PREVENTION AND TREATMENT

COBRE：UD：管理核心：骨关节炎：预防和治疗

• 批准号: 8167631
• 负责人: Thomas S Buchanan
• 金额: $ 86.95万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8167631
• 关键词: Address; Area; Arthritis; Basic Science; Biomechanics; Biomedical Engineering; Centers of Research Excellence; Clinic; Clinical; Clinical Treatment; Computer Retrieval of Information on Scientific Projects Database; Core Facility; Degenerative polyarthritis; Delaware; Engineering; Faculty; Foundations; Funding; Goals; Grant; Institution; Intervention; Lead; Mechanics; Mentors; Physical therapy; Prevention; Research; Research Infrastructure; Research Personnel; Research Project Grants; Resources; Science; Source; Tissues; Training; United States National Institutes of Health; Universities; Woman; Work; base; bioimaging; college; instrumentation; member; multidisciplinary; tool; translational medicine; trend

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this COBRE II grant we aim to develop multidisciplinary researchers in the field of osteoarthritis (OA), from the lab bench to the clinic, with a unique focus on mentoring Women In Science and Engineering (WISE). In this proposal, each of the five projects is lead by a women faculty member. Women faculty in science, and especially engineering, are under-represented. At the University of Delaware, women make up 17% of the faculty of science and 10% of the faculty in engineering. Delaware is not unique in this regard. National averages show similar trends (Nelson, 2005). Thus, our aim is to provide a forum for mentoring and promoting women faculty working in the field of arthritis research. This COBRE II grant, as is COBRE I grant, is administered through our Center for Biomedical Engineering Research (CBER) at the University of Delaware. CBER has been in existence since the early 1990's and provides a forum for researchers in different departments to work together on mulitidisciplinary projects related to translational medicine using biomedical engineering tools. Without exception, all of the research grants through the center (which are mostly R01s) have faculty from at least two colleges working together on multidisciplinary projects that tie together both basic research and clinical treatment. The scientific goal of this COBRE II grant is to create the infrastructure and expertise base to address the mechanisms of OA, as well as its prevention and treatment. The uniqueness of the approach to be employed by our center will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, physical therapy and clinical intervention. A foundation for this has been laid by our initial COBRE I grant. In our proposed work, we will build upon the distinctive organization of CBER and the collaborative projects described in this application. In addition to the integration provided by the overarching research aims of the Center, as mentioned above, we aim to establish a core facility for mentoring women in science and engineering. We also aim to continue and expand our instrumentation core in the area of biomedical imaging. Multiple projects benefit from the core facilities provided by the Center. We also encourage other faculty at the University that are not directly involved in the Center to make use of these cores, and will provide mentoring, technical staff and training to make such benefits more accessible.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 在这项 COBRE II 资助中，我们的目标是培养骨关节炎 (OA) 领域的多学科研究人员，从实验室到临床，特别注重指导科学与工程领域的女性 (WISE)。在该提案中，五个项目均由一名女教员领导。科学界，尤其是工程学界的女性教师代表性不足。在特拉华大学，女性占理学院教师的 17%，占工程学院教师的 10%。特拉华州在这方面并不是独一无二的。全国平均水平也显示出类似的趋势（Nelson，2005）。因此，我们的目标是提供一个论坛来指导和促进在关节炎研究领域工作的女性教师。 该 COBRE II 赠款与 COBRE I 赠款一样，由特拉华大学生物医学工程研究中心 (CBER) 管理。 CBER 自 1990 年代初就已存在，为不同部门的研究人员提供了一个论坛，让他们能够利用生物医学工程工具共同开展与转化医学相关的多学科项目。无一例外，该中心的所有研究经费（大部分是 R01）都有来自至少两所学院的教员共同致力于将基础研究和临床治疗结合起来的多学科项目。 COBRE II 赠款的科学目标是创建基础设施和专业知识基础，以解决 OA 的机制及其预防和治疗问题。我们中心采用的方法的独特之处在于从组织力学、生物力学、物理治疗和临床干预的综合角度对骨关节炎进行检查。我们最初的 COBRE I 拨款为此奠定了基础。在我们提出的工作中，我们将建立在 CBER 的独特组织和本申请中描述的协作项目的基础上。 除了如上所述该中心的总体研究目标所提供的整合之外，我们的目标是建立一个核心设施，以指导科学和工程领域的女性。我们还致力于继续并扩展我们在生物医学成像领域的仪器核心。多个项目受益于该中心提供的核心设施。我们还鼓励大学中不直接参与该中心的其他教员利用这些核心，并将提供指导、技术人员和培训，以使这些好处更容易获得。