COBRE: UD: ADMININSTRATION CORE: OSTEOARTHRITIS: PREVENTION AND TREATMENT

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在这个COBRE II补助金，我们的目标是开发骨关节炎（OA）领域的多学科研究人员，从实验室工作台到诊所，以指导科学和工程（WISE）女性的独特重点。在该提案中，五个项目中的每一个都由一名女教员领导。理科，特别是工科的女教师人数不足。在特拉华州大学，女性占理学院的17%，占工学院的10%。在这方面，特拉华州并不是独一无二的。全国平均数显示出类似的趋势（纳尔逊，2005年）。因此，我们的目标是提供一个论坛，指导和促进妇女教师在关节炎研究领域的工作。 这个COBRE II补助金，作为COBRE I补助金，是通过我们的生物医学工程研究中心（CBER）在特拉华州大学管理。CBER自20世纪90年代初以来一直存在，并为不同部门的研究人员提供了一个论坛，共同致力于使用生物医学工程工具进行与转化医学相关的多学科项目。毫无例外，通过该中心的所有研究赠款（主要是R 01）都有来自至少两所学院的教师共同从事多学科项目，将基础研究和临床治疗联系在一起。 COBRE II赠款的科学目标是建立基础设施和专业知识基础，以解决OA的机制及其预防和治疗。我们中心采用的方法的独特之处在于从组织力学、生物力学、物理治疗和临床干预的综合角度来检查OA。我们最初的COBRE I赠款为此奠定了基础。在我们提出的工作中，我们将建立在CBER的独特组织和本申请中描述的合作项目的基础上。 除了中心的总体研究目标提供的整合外，如上所述，我们的目标是建立一个指导科学和工程领域妇女的核心设施。我们的目标是继续和扩大我们在生物医学成像领域的仪器核心。多个项目受益于中心提供的核心设施。我们还鼓励没有直接参与该中心的大学其他教师利用这些核心，并将提供指导，技术人员和培训，使这些好处更容易获得。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In this COBRE II grant we aim to develop multidisciplinary researchers in the field of osteoarthritis (OA), from the lab bench to the clinic, with a unique focus on mentoring Women In Science and Engineering (WISE). In this proposal, each of the five projects is lead by a women faculty member. Women faculty in science, and especially engineering, are under-represented. At the University of Delaware, women make up 17% of the faculty of science and 10% of the faculty in engineering. Delaware is not unique in this regard. National averages show similar trends (Nelson, 2005). Thus, our aim is to provide a forum for mentoring and promoting women faculty working in the field of arthritis research. This COBRE II grant, as is COBRE I grant, is administered through our Center for Biomedical Engineering Research (CBER) at the University of Delaware. CBER has been in existence since the early 1990's and provides a forum for researchers in different departments to work together on mulitidisciplinary projects related to translational medicine using biomedical engineering tools. Without exception, all of the research grants through the center (which are mostly R01s) have faculty from at least two colleges working together on multidisciplinary projects that tie together both basic research and clinical treatment. The scientific goal of this COBRE II grant is to create the infrastructure and expertise base to address the mechanisms of OA, as well as its prevention and treatment. The uniqueness of the approach to be employed by our center will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, physical therapy and clinical intervention. A foundation for this has been laid by our initial COBRE I grant. In our proposed work, we will build upon the distinctive organization of CBER and the collaborative projects described in this application. In addition to the integration provided by the overarching research aims of the Center, as mentioned above, we aim to establish a core facility for mentoring women in science and engineering. We also aim to continue and expand our instrumentation core in the area of biomedical imaging. Multiple projects benefit from the core facilities provided by the Center. We also encourage other faculty at the University that are not directly involved in the Center to make use of these cores, and will provide mentoring, technical staff and training to make such benefits more accessible.