COBRE for Women in Science & Engineering on Osteoarthritis

描述(由申请者提供)：在这份申请中，我们建议提供一个多学科平台，指导科学和工程(WISE)的女性在骨关节炎研究方面取得成功。这是建立在我们的第一个生物医学研究卓越中心(COBRE)骨关节炎(OA)奖的基础上的。该申请中的每个项目都由一名女性教员领导，所有初级教员都将有科学导师和职业导师帮助他们在NIH的支持下过渡到终身教员。在我们的三管齐下的方法中，我们将建立外部网络、内部指导和大学范围的项目，以提高机构对性别问题的认识。科布尔奖通过我们位于特拉华大学的生物医学工程研究中心(CBER)运作。该中心的目标是创建基础设施和专业知识基础，以解决骨关节炎的机制，以及其预防和治疗。我们中心所采用的方法的独特之处将是从生物化学、组织力学、生物力学、物理治疗和临床干预的综合、多学科的翻译角度对骨关节炎进行检查。拟议计划中的一些核心科学专业领域在特拉华大学已经很成熟，但它们传统上分布在不同系的不同实验室，初级教职员工的参与很少。在我们拟议的工作背景下，我们将建立在与科布尔奖和本申请中描述的合作项目建立的CBER独特组织的基础上。将在该中心的框架下执行五个次级项目。这些子项目是多学科的，参与者来自工程学院、艺术与科学学院和健康科学学院的多个学术单位。这些项目的题目是(1)Perlecan和Heparanase在软骨生长和愈合中，(2)骨关节炎关节软骨下骨板中的溶质运输，(3)膝骨性关节炎进展的危险因素，(4)全膝关节置换术(TKA)后的关节负荷和骨性关节炎的进展，以及(5)膝关节僵硬、原始感觉和不稳定影响膝关节控制。

Description (provided by applicant): In this application, we propose to provide a multidisciplinary platform for mentoring women in science and engineering (WISE) to have sucessful careers in osteoarthritis research. This builds on the work of our first Center of Biomedical Research Excellence (COBRE) award on osteoarthritis (OA). Each project in this application is led by a women faculty member and all junior faculty will have scientific mentors and career mentors to help them in the transition to becoming tenured faculty with NIH support. In our three-pronged approach, we will extablish external networks, internal mentoring, and university-wide programs to increase institutional awareness of gender issues. This COBRE award operates through our Center for BiomedicalEngineering Research (CBER) at the University of Delaware. The aim of the Center is to create theinfrastructure and expertise base to address the mechanisms of OA, as well as its prevention and treatment.The uniqueness of the approach to be employed by our center will be the examination of OA from theintegrated, multidisciplinary translational perspectives of biochemistry, tissue mechanics, biomechanics,physical therapy and clinical intervention. Some of the core scientific areas of expertise in the proposedprogram are well-established at the University of Delaware, but they have traditionally been spread acrossdifferent laboratories in different departments and have minimal involvement of junior faculty members. In the context of our proposed work, we will build upon the distinctive organization of CBER established with the COBRE award and the collaborative projects described in this application. Five subprojects will be carried out under the Center umbrella. The subprojects are multidisciplinary and the participants are drawn from multiple academic units in the Colleges of Engineering, Arts & Sciences, and Health Sciences. The projecttitles are (1) Perlecan and Heparanase in Cartilage Growth and Healing, (2) Solute Transport in theSubchondral Bone Plate of Osteoarthritic Joints, (3) Risk Factors for Progression of Osteoarthritis of the Knee, (4) Joint Loading and the Progression of Osteoarthritis following Total Knee Arthroplasty (TKA), and (5) Knee Stiffness, Proprioception and Instability affect Knee Control in OA.