Osteoarthritis: Prevention and Treatment

骨关节炎：预防和治疗

• 批准号: 8518409
• 负责人: Thomas S Buchanan
• 金额: $ 107.19万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8518409
• 关键词: Address; Advisory Committees; Affect; American; Arthritis; Award; Biomechanics; Biometry; Cartilage; Centers of Research Excellence; Clinical; Clinical Research; Clinical Trials; Collection; Coupled; Databases; Degenerative polyarthritis; Delaware; Development; Disease; Engineering; Extracellular Matrix Proteins; Faculty; Feedback; Foundations; Funding; Future; Goals; Grant; Human; Joints; Life; Ligaments; Mechanics; Medicine; Mentors; Modeling; Modification; Motion; Muscle; Orthopedics; Outcome; Outcome Study; Pathology; Patients; Phase; Pilot Projects; Prevention; Rehabilitation therapy; Research; Research Infrastructure; Research Personnel; Resources; Running; Science; Stress; Testing; Time; Tissues; United States National Institutes of Health; Universities; Woman; Work; base; bioimaging; bone; improved; member; multidisciplinary; public health relevance; success; tool; translational approach; trend

DESCRIPTION (provided by applicant): We propose to build on the successes of our of past COBRE phase I and II grants to create a collection of three research cores that, coupled with a pilot project mechanism, will provide us with the resources to develop a strong team of investigators to study the prevention and treatment of osteoarthritis. Ours is a multidisciplinary, multi-scale approach to the study of osteoarthritis (OA), involving faculty doing work in extracellular matrix proteins, biomechanical modeling of joint forces, and clinical studies. The uniqueness of our approach will be the examination of OA from the integrated perspectives of tissue mechanics, biomechanics, and rehabilitation. We will build on the distinctive organization of the center established with the COBRE award and the collaborative projects described in this application. Three core resources will be run through this award: (1) A cytomechanics core, first established in our phase II grant, will be strengthened to provide tools for orthopaedic researchers to study how bone, cartilage and ligament respond to stress and strain. This involves tools for bioimaging and micromechanical testing. (2) A patient specific modeling (PSM) core will be established. This is a modification and expansion of the motion analysis core established in our COBRE I award. It will provide a means to determine differences in tissue forces associated with pathologies and will also be used to determine biomechanical differences associated with various treatment paths, which may impact the development of osteoarthritis. (3) A clinical research core (the ResCore) will be established for the first time to aid us as we expand our clinical trials. It will provide patient database access and biostatistics support for al projects. In addition, we will continue to maintain our mentoring mechanism. Faculty development is key to our success and we will continue to mentor our faculty and work with our External Advisory Committee to provide very regular feedback to COBRE investigators about their research. Our goal is to use these resources to establish a large base of NIH R01 funded investigators studying osteoarthritis and, by those R01 grants, be able to support our cores in the future and greatly expand our efforts to make strong progress in understanding the prevention and treatment of OA.

描述（由申请人提供）：我们建议在过去COBRE I期和II期赠款的成功基础上，创建一个由三个研究核心组成的集合，再加上试点项目机制，将为我们提供资源，以开发强大的研究人员团队来研究骨关节炎的预防和治疗。我们的是一个多学科， 骨关节炎（OA）研究的多尺度方法，涉及从事细胞外基质蛋白，关节力生物力学建模和临床研究的教师。我们的方法的独特性将是从组织力学，生物力学和康复的综合角度来检查OA。我们将建立在与COBRE奖和本申请中描述的合作项目建立的中心的独特组织。三个核心资源将通过这个奖项运行：（1）细胞力学核心，首先建立在我们的第二阶段资助，将加强为骨科研究人员提供工具，研究如何骨，软骨和韧带对应力和应变的反应。这涉及生物成像和微机械测试的工具。(2)将建立患者特定建模（PSM）核心。这是对我们COBRE I奖项中建立的运动分析核心的修改和扩展。它将提供一种确定与病理相关的组织力差异的方法，还将用于确定与各种治疗路径相关的生物力学差异，这可能会影响骨关节炎的发展。(3)将首次建立一个临床研究核心（ResCore），以帮助我们扩大临床试验。它将为al项目提供患者数据库访问和生物统计支持。此外，我们将继续维持我们的辅导机制。教师发展是我们成功的关键，我们将继续指导我们的教师，并与我们的外部咨询委员会合作，为COBRE研究人员提供关于他们研究的定期反馈。我们的目标是利用这些资源建立一个由NIH R01资助的研究骨关节炎的大型研究者基地，并通过这些R01赠款，能够在未来支持我们的核心，并大大扩大我们的努力，在理解OA的预防和治疗方面取得重大进展。