PREVALENCE OF CYSTIC FIBROSIS RELATED DIABETES AMONG NATIVE AMERICANS IN OK

俄克拉何马州原住民中囊性纤维化相关糖尿病的患病率

• 批准号: 7608095
• 负责人: KENNETH C COPELAND
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608095
• 关键词: Complication; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Diabetes Mellitus; Ethnic Origin; Functional disorder; Funding; Genetic Predisposition to Disease; Goals; Grant; Hour; Inherited; Institution; Native Americans; OGTT; Patient Self-Report; Prevalence; Research; Research Personnel; Resources; Risk; Source; United States National Institutes of Health; cystic fibrosis patients; glucose tolerance; impaired glucose tolerance; theories

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cystic fibrosis related diabetes (CFRD) is becoming an increasingly common complication of cystic fibrosis (CF). The pathophysiology of CFRD remains unclear; however an inherited risk for type 2 DM has been a proposed theory, yet it remains unproven. The goal of this study is to estimate the proportion of patients with CF and impaired glucose tolerance (IGT) or cystic fibrosis related diabetes. The relationship between glucose tolerance status and self reported ethnicity, particularly of Native American descent will be used to determine the possibility of an inherited predisposition to diabetes. Glucose tolerance status will be determined by using a 2 hour oral glucose tolerance test (OGTT) and correlated with Native American ethnicity status.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 囊性纤维化相关糖尿病（CFRD）正成为囊性纤维化（CF）的一种越来越常见的并发症。 CFRD的病理生理学尚不清楚;然而，2型糖尿病的遗传风险已被提出理论，但仍未得到证实。 本研究的目的是估计CF和糖耐量受损（IGT）或囊性纤维化相关糖尿病患者的比例。 葡萄糖耐量状态和自我报告的种族之间的关系，特别是美洲原住民血统，将用于确定遗传易感性糖尿病的可能性。 将通过2小时口服葡萄糖耐量试验（OGTT）确定葡萄糖耐量状态，并与美洲原住民种族状态相关联。