TREATMENT OF UNSUSTAINED HYPERGLYCEMIA IN PATIENTS WITH CYSTIC FIBROSIS

囊性纤维化患者不持续高血糖的治疗

• 批准号: 7608098
• 负责人: KENNETH C COPELAND
• 金额: $ 0.12万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7608098
• 关键词: Body Weight decreased; Case Study; Computer Retrieval of Information on Scientific Projects Database; Cystic Fibrosis; Diabetes Mellitus; Funding; Glucose; Goals; Grant; Hyperglycemia; Institution; Insulin; Literature; Measures; Metabolism; Morbidity - disease rate; Patients; Replacement Therapy; Research; Research Personnel; Resources; Source; Thinking; United States National Institutes of Health; Weight; Weight Gain; cystic fibrosis patients; impaired glucose tolerance; improved; pulmonary function

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current literature indicates that cystic fibrosis patients with insulin deficiency and impaired glucose tolerance have an increased morbidity compared to the normal glucose tolerant CF patients. Worsening pulmonary function and weight loss is thought to be related to the catabolic state that is seen in patients with impaired glucose tolerance and insulin deficiency with or without cystic fibrosis. Case reports have shown that cystic fibrosis patients with abnormal glucose levels who do not have diabetes had improvement in both weight and pulmonary function with insulin replacement therapy. The goal of this study is to objectively measure changes in metabolism before and after initiation of insulin treatment and its possible relation to improved pulmonary function and increase weight.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 目前的文献表明，与正常糖耐量囊性纤维化患者相比，胰岛素缺乏和糖耐量受损的囊性纤维化患者的发病率更高。 肺功能恶化和体重减轻被认为与糖耐量受损和胰岛素缺乏（伴或不伴囊性纤维化）患者的分解代谢状态有关。 病例报告显示，血糖水平异常但未患有糖尿病的囊性纤维化患者通过胰岛素替代疗法，体重和肺功能均得到改善。 本研究的目的是客观测量胰岛素治疗开始前后代谢的变化及其与改善肺功能和增加体重的可能关系。