DASH diet, cardiovascular hemodynamics and type II diabetes mellitus

描述（由申请人提供）：本申请的目的是为Jonathan Williams医学博士提供保护时间，使他成为一名成功的独立的、以患者为导向的研究人员，研究影响2型糖尿病（DM）心血管功能的激素机制。布里格姆妇女医院及其一流的综合临床研究中心将为开展所提出的研究提供理想的环境，并为培养真正的跨学科研究人员提供独特的机会。实现这一目标的关键是他获得三个重要工具的能力：1)在他的研究领域进行详细的教学培训；2)学科和组织专业知识；3)进行以患者为导向的研究所需的实践技能。为了实现这一目标，他将参加高级教学课程，并在Paul Conlin博士的指导下进行以患者为导向的指导研究项目。Williams博士的建议扩展了饮食方法来阻止高血压（DASH）研究的发现，该研究表明饮食摄入可以显着降低血压。DASH饮食对高血压患者特别有效，但我们不知道DASH饮食是如何起作用的，除了它的降血压作用外，我们不知道DASH饮食是否会更广泛地影响糖尿病患者心血管系统的结构和功能异常。我们的初步数据强烈支持DASH饮食中断心血管组织肾素-血管紧张素系统的可能性。这些和其他数据提出了一种有趣的可能性，即DASH饮食产生类似血管紧张素转换酶（ACE）抑制的效果。这样的效果将为患有糖尿病固有心血管风险因素的个体提供明显的益处。在该提案中，Williams博士将介绍他在研究培训中获得的技术和技能，以回答DASH饮食如何影响糖尿病心血管功能的问题。该奖项将提供受保护的时间和资源，以(1)巩固他的教学培训，(2)设计、实施和完成一个以患者为导向的研究项目。(3)继续受到其研究领域领导者的指导。这将为他在心血管内分泌学领域建立独立的、以患者为导向的研究事业提供一条清晰的道路。

DESCRIPTION (provided by applicant): The goal of this application is to provide protected time for Jonathan Williams, M.D. to become a successful independent, patient-oriented research investigator in the field of hormonal mechanisms affecting cardiovascular function in type II diabetes mellitus (DM). Brigham and Women's Hospital and its top-notch General Clinical Research Center will provide an ideal setting in which to peform the studies proposed and a unique opportunity to train a truly interdisciplinary researcher. Critical to obtaining this goal is his ability to acquire three important tools: 1) detailed didactic training in his field of investigation, 2) discipline and organizational expertise and 3) the practical skills necessary to conduct patient-oriented research. To accomplish this, he will participate in advanced didactic courses and conduct a mentored patient-oriented research project under the mentorship of Dr. Paul Conlin. Dr. Williams' proposal expands upon the findings of the Dietary Approaches to Stop Hypertension (DASH) studies, which showed that dietary intake could significantly lower blood pressure. The DASH diet is particularly effective in individuals with hypertension, yet we do not know how the DASH diet works and, beyond its blood pressure lowering effects, we do not know whether the DASH diet might more broadly affect structural and functional abnormalities in the cardiovasculature that frequently accompany patients with DM. Our preliminary data strongly support the possibility that the DASH diet interrupts the renin-angiotensin system in cardiovascular tissues. These and other data raise the intriguing possibility that the DASH diet produces effects that mimic angiotensin converting enzyme (ACE) inhibition. Such effects would offer clear benefits to individuals with the cardiovascular risk factors inherent in DM. In this proposal, Dr. Williams will introduce techniques and skills acquired during his research training to answer the question how the DASH diet affects cardiovascular function in DM. This award will provide the protected time and resources to (1) solidify his didactic training, (2) design, conduct, and complete a patient-oriented research project, and (3) continue to be mentored by leaders in his field of study. It will provide a clear pathway for him to establish an independent patient- oriented research career in cardiovascular endocrinology.