DASH diet, cardiovascular hemodynamics and type II diabetes mellitus

DASH 饮食、心血管血流动力学和 II 型糖尿病

• 批准号: 7363628
• 负责人: JONATHAN S. WILLIAMS
• 金额: $ 14万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7363628
• 关键词: Affect; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Antioxidants; Award; Biological Assay; Blood Pressure; Blood Vessels; Captopril; Cardiac; Cardiovascular Physiology; Cardiovascular system; Cessation of life; Characteristics; Clinical Research; Coupled; Dairy Products; Data; Diabetes Mellitus; Diet; Dietary Component; Dietary intake; Discipline; Doctor of Medicine; Eating; Endocrinology; Enzyme Inhibition; Event; Fatty acid glycerol esters; Functional disorder; Generations; Genotype; Goals; Homocysteine; Homocystine; Hormonal; Hospitals; Hypertension; Hypotension; Image; Individual; Infusion procedures; Injury; Intervention; Investigation; Kidney; LDL Cholesterol Lipoproteins; Link; Losartan; Measurable; Measurement; Measures; Mentors; Mentorship; Myocardial; Natriuresis; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pathology; Pathway interactions; Patients; Pattern; Peptidyl-Dipeptidase A; Peripheral; Physiologic pulse; Physiological; Plasma; Population; Pulse Pressure; Pulse taking; Randomized; Relaxation; Renal Blood Flow; Renal Circulation; Renin; Renin-Angiotensin System; Research; Research Personnel; Research Project Grants; Research Training; Resistance; Resources; Risk Factors; Role; Running; Serum; Sodium; Sodium Chloride; Techniques; Testing; Time; Tissues; Training; Translations; Vascular blood supply; Week; Woman; Work; base; cardiovascular risk factor; career; clinically relevant; design; electric impedance; feeding; field study; fruits and vegetables; hemodynamics; improved; improved functioning; interest; kidney vascular structure; notch protein; patient oriented research; pressure; response; saturated fat; skills; tool

DESCRIPTION (provided by applicant): The goal of this application is to provide protected time for Jonathan Williams, M.D. to become a successful independent, patient-oriented research investigator in the field of hormonal mechanisms affecting cardiovascular function in type II diabetes mellitus (DM). Brigham and Women's Hospital and its top-notch General Clinical Research Center will provide an ideal setting in which to peform the studies proposed and a unique opportunity to train a truly interdisciplinary researcher. Critical to obtaining this goal is his ability to acquire three important tools: 1) detailed didactic training in his field of investigation, 2) discipline and organizational expertise and 3) the practical skills necessary to conduct patient-oriented research. To accomplish this, he will participate in advanced didactic courses and conduct a mentored patient-oriented research project under the mentorship of Dr. Paul Conlin. Dr. Williams' proposal expands upon the findings of the Dietary Approaches to Stop Hypertension (DASH) studies, which showed that dietary intake could significantly lower blood pressure. The DASH diet is particularly effective in individuals with hypertension, yet we do not know how the DASH diet works and, beyond its blood pressure lowering effects, we do not know whether the DASH diet might more broadly affect structural and functional abnormalities in the cardiovasculature that frequently accompany patients with DM. Our preliminary data strongly support the possibility that the DASH diet interrupts the renin-angiotensin system in cardiovascular tissues. These and other data raise the intriguing possibility that the DASH diet produces effects that mimic angiotensin converting enzyme (ACE) inhibition. Such effects would offer clear benefits to individuals with the cardiovascular risk factors inherent in DM. In this proposal, Dr. Williams will introduce techniques and skills acquired during his research training to answer the question how the DASH diet affects cardiovascular function in DM. This award will provide the protected time and resources to (1) solidify his didactic training, (2) design, conduct, and complete a patient-oriented research project, and (3) continue to be mentored by leaders in his field of study. It will provide a clear pathway for him to establish an independent patient- oriented research career in cardiovascular endocrinology.

描述（由申请人提供）：本申请的目的是为医学博士 Jonathan Williams 提供受保护的时间，使其成为影响 II 型糖尿病 (DM) 心血管功能的激素机制领域成功的独立、以患者为导向的研究调查员。布莱根妇女医院及其一流的普通临床研究中心将为开展所提出的研究提供理想的环境，并为培养真正的跨学科研究人员提供独特的机会。实现这一目标的关键是他获得三个重要工具的能力：1）其研究领域的详细教学培训，2）学科和组织专业知识，3）进行以患者为导向的研究所需的实践技能。为了实现这一目标，他将参加高级教学课程，并在 Paul Conlin 博士的指导下开展一项以患者为导向的研究项目。威廉姆斯博士的提议扩展了控制高血压饮食方法 (DASH) 研究的结果，该研究表明饮食摄入可以显着降低血压。 DASH 饮食对高血压患者特别有效，但我们不知道 DASH 饮食是如何发挥作用的，除了其降低血压的作用之外，我们不知道 DASH 饮食是否可能更广泛地影响糖尿病患者经常出现的心血管结构和功能异常。我们的初步数据强烈支持 DASH 饮食中断心血管组织中的肾素-血管紧张素系统的可能性。这些数据和其他数据提出了一种有趣的可能性，即 DASH 饮食产生模仿血管紧张素转换酶 (ACE) 抑制的效果。这种效应将为患有糖尿病固有心血管危险因素的个体带来明显的益处。在本提案中，Williams 博士将介绍他在研究培训期间获得的技术和技能，以回答 DASH 饮食如何影响 DM 心血管功能的问题。该奖项将提供受保护的时间和资源，以（1）巩固他的教学培训，（2）设计、开展和完成以患者为导向的研究项目，以及（3）继续接受其研究领域领导者的指导。这将为他在心血管内分泌学领域建立独立的、以患者为导向的研究生涯提供一条清晰的途径。