DASH diet, cardiovascular hemodynamics and type II diabetes mellitus

DASH 饮食、心血管血流动力学和 II 型糖尿病

• 批准号: 7188454
• 负责人: JONATHAN S. WILLIAMS
• 金额: $ 14.17万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7188454
• 关键词: Affect; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Antioxidants; Award; Biological Assay; Blood Pressure; Blood Vessels; Captopril; Cardiac; Cardiovascular Physiology; Cardiovascular system; Cessation of life; Characteristics; Clinical Research; Coupled; Dairy Products; Data; Diabetes Mellitus; Diet; Dietary Component; Dietary intake; Discipline; Doctor of Medicine; Eating; Endocrinology; Enzyme Inhibition; Event; Fatty acid glycerol esters; Functional disorder; Generations; Genotype; Goals; Homocysteine; Homocystine; Hormonal; Hospitals; Hypertension; Hypotension; Image; Individual; Infusion procedures; Injury; Intervention; Investigation; Kidney; LDL Cholesterol Lipoproteins; Link; Losartan; Measurable; Measurement; Measures; Mentors; Mentorship; Myocardial; Natriuresis; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pathology; Pathway interactions; Patients; Pattern; Peptidyl-Dipeptidase A; Peripheral; Physiologic pulse; Physiological; Plasma; Population; Pulse Pressure; Pulse taking; Randomized; Relaxation; Renal Blood Flow; Renal Circulation; Renin; Renin-Angiotensin System; Research; Research Personnel; Research Project Grants; Research Training; Resistance; Resources; Risk Factors; Role; Running; Serum; Sodium; Sodium Chloride; Techniques; Testing; Time; Tissues; Training; Translations; Vascular blood supply; Week; Woman; Work; base; cardiovascular risk factor; career; clinically relevant; design; electric impedance; feeding; field study; fruits and vegetables; hemodynamics; improved; improved functioning; interest; kidney vascular structure; notch protein; patient oriented research; pressure; response; saturated fat; skills; tool

DESCRIPTION (provided by applicant): The goal of this application is to provide protected time for Jonathan Williams, M.D. to become a successful independent, patient-oriented research investigator in the field of hormonal mechanisms affecting cardiovascular function in type II diabetes mellitus (DM). Brigham and Women's Hospital and its top-notch General Clinical Research Center will provide an ideal setting in which to peform the studies proposed and a unique opportunity to train a truly interdisciplinary researcher. Critical to obtaining this goal is his ability to acquire three important tools: 1) detailed didactic training in his field of investigation, 2) discipline and organizational expertise and 3) the practical skills necessary to conduct patient-oriented research. To accomplish this, he will participate in advanced didactic courses and conduct a mentored patient-oriented research project under the mentorship of Dr. Paul Conlin. Dr. Williams' proposal expands upon the findings of the Dietary Approaches to Stop Hypertension (DASH) studies, which showed that dietary intake could significantly lower blood pressure. The DASH diet is particularly effective in individuals with hypertension, yet we do not know how the DASH diet works and, beyond its blood pressure lowering effects, we do not know whether the DASH diet might more broadly affect structural and functional abnormalities in the cardiovasculature that frequently accompany patients with DM. Our preliminary data strongly support the possibility that the DASH diet interrupts the renin-angiotensin system in cardiovascular tissues. These and other data raise the intriguing possibility that the DASH diet produces effects that mimic angiotensin converting enzyme (ACE) inhibition. Such effects would offer clear benefits to individuals with the cardiovascular risk factors inherent in DM. In this proposal, Dr. Williams will introduce techniques and skills acquired during his research training to answer the question how the DASH diet affects cardiovascular function in DM. This award will provide the protected time and resources to (1) solidify his didactic training, (2) design, conduct, and complete a patient-oriented research project, and (3) continue to be mentored by leaders in his field of study. It will provide a clear pathway for him to establish an independent patient- oriented research career in cardiovascular endocrinology.

描述(申请人提供)：本申请的目的是为乔纳森·威廉姆斯医学博士在影响II型糖尿病(DM)心血管功能的荷尔蒙机制领域成为一名成功的独立、以患者为导向的研究调查员提供保护时间。布里格姆妇女医院及其顶尖的综合临床研究中心将提供一个理想的环境来实施所提出的研究，并提供一个独特的机会来培养真正的跨学科研究人员。实现这一目标的关键是他获得三个重要工具的能力：1)在他的调查领域进行详细的说教培训，2)纪律和组织专业知识，3)进行以病人为导向的研究所需的实践技能。为了实现这一目标，他将参加高级教学课程，并在保罗·柯林博士的指导下进行以患者为导向的指导研究项目。威廉姆斯博士的建议是对阻止高血压的饮食方法(DASH)研究结果的扩展，这些研究表明，饮食摄入可以显著降低血压。DASH饮食对高血压患者特别有效，但我们不知道DASH饮食是如何起作用的，除了它的降压作用外，我们也不知道DASH饮食是否会更广泛地影响经常伴随糖尿病患者的心血管结构和功能异常。我们的初步数据有力地支持了DASH饮食干扰心血管组织中肾素-血管紧张素系统的可能性。这些数据和其他数据提出了一种有趣的可能性，即DASH饮食产生的效果类似于血管紧张素转换酶(ACE)抑制。这样的影响将为具有糖尿病固有心血管危险因素的个人提供明显的好处。在这份提案中，威廉姆斯博士将介绍他在研究培训期间获得的技术和技能，以回答DASH饮食如何影响糖尿病患者心血管功能的问题。这一奖项将提供受保护的时间和资源，以(1)巩固他的教学培训，(2)设计、实施和完成以患者为中心的研究项目，以及(3)继续接受他所在研究领域的领导的指导。这将为他在心血管内分泌学领域建立独立的、以患者为导向的研究生涯提供一条明确的途径。