DASH diet, cardiovascular hemodynamics and type II diabetes mellitus

DASH 饮食、心血管血流动力学和 II 型糖尿病

• 批准号: 7188454
• 负责人: JONATHAN S. WILLIAMS
• 金额: $ 14.17万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2012-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7188454
• 关键词: Affect; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Antioxidants; Award; Biological Assay; Blood Pressure; Blood Vessels; Captopril; Cardiac; Cardiovascular Physiology; Cardiovascular system; Cessation of life; Characteristics; Clinical Research; Coupled; Dairy Products; Data; Diabetes Mellitus; Diet; Dietary Component; Dietary intake; Discipline; Doctor of Medicine; Eating; Endocrinology; Enzyme Inhibition; Event; Fatty acid glycerol esters; Functional disorder; Generations; Genotype; Goals; Homocysteine; Homocystine; Hormonal; Hospitals; Hypertension; Hypotension; Image; Individual; Infusion procedures; Injury; Intervention; Investigation; Kidney; LDL Cholesterol Lipoproteins; Link; Losartan; Measurable; Measurement; Measures; Mentors; Mentorship; Myocardial; Natriuresis; Non-Insulin-Dependent Diabetes Mellitus; Participant; Pathology; Pathway interactions; Patients; Pattern; Peptidyl-Dipeptidase A; Peripheral; Physiologic pulse; Physiological; Plasma; Population; Pulse Pressure; Pulse taking; Randomized; Relaxation; Renal Blood Flow; Renal Circulation; Renin; Renin-Angiotensin System; Research; Research Personnel; Research Project Grants; Research Training; Resistance; Resources; Risk Factors; Role; Running; Serum; Sodium; Sodium Chloride; Techniques; Testing; Time; Tissues; Training; Translations; Vascular blood supply; Week; Woman; Work; base; cardiovascular risk factor; career; clinically relevant; design; electric impedance; feeding; field study; fruits and vegetables; hemodynamics; improved; improved functioning; interest; kidney vascular structure; notch protein; patient oriented research; pressure; response; saturated fat; skills; tool

DESCRIPTION (provided by applicant): The goal of this application is to provide protected time for Jonathan Williams, M.D. to become a successful independent, patient-oriented research investigator in the field of hormonal mechanisms affecting cardiovascular function in type II diabetes mellitus (DM). Brigham and Women's Hospital and its top-notch General Clinical Research Center will provide an ideal setting in which to peform the studies proposed and a unique opportunity to train a truly interdisciplinary researcher. Critical to obtaining this goal is his ability to acquire three important tools: 1) detailed didactic training in his field of investigation, 2) discipline and organizational expertise and 3) the practical skills necessary to conduct patient-oriented research. To accomplish this, he will participate in advanced didactic courses and conduct a mentored patient-oriented research project under the mentorship of Dr. Paul Conlin. Dr. Williams' proposal expands upon the findings of the Dietary Approaches to Stop Hypertension (DASH) studies, which showed that dietary intake could significantly lower blood pressure. The DASH diet is particularly effective in individuals with hypertension, yet we do not know how the DASH diet works and, beyond its blood pressure lowering effects, we do not know whether the DASH diet might more broadly affect structural and functional abnormalities in the cardiovasculature that frequently accompany patients with DM. Our preliminary data strongly support the possibility that the DASH diet interrupts the renin-angiotensin system in cardiovascular tissues. These and other data raise the intriguing possibility that the DASH diet produces effects that mimic angiotensin converting enzyme (ACE) inhibition. Such effects would offer clear benefits to individuals with the cardiovascular risk factors inherent in DM. In this proposal, Dr. Williams will introduce techniques and skills acquired during his research training to answer the question how the DASH diet affects cardiovascular function in DM. This award will provide the protected time and resources to (1) solidify his didactic training, (2) design, conduct, and complete a patient-oriented research project, and (3) continue to be mentored by leaders in his field of study. It will provide a clear pathway for him to establish an independent patient- oriented research career in cardiovascular endocrinology.

描述（由申请人提供）：本申请的目的是为乔纳森·威廉姆斯（Jonathan Williams）提供受保护的时间，以成为一名成功的独立，以患者为导向的研究研究者，该研究者在影响II型糖尿病型心血管功能的激素机制领域，梅洛蒂斯（Mellitus）（DM）。 Brigham and妇女医院及其一流的一般临床研究中心将提供一个理想的环境，在该环境中，可以在其中提出的研究以及一个独特的机会来培训真正的跨学科研究人员。获得这个目标至关重要的是他能够获得三个重要工具的能力：1）在他的调查领域中详细的教学培训，2）纪律和组织专业知识以及3）进行面向患者的研究所需的实用技能。为此，他将参加先进的教学课程，并在Paul Conlin博士的指导下开展以患者为导向的研究项目。威廉姆斯博士的提议扩大了饮食中停止高血压（DASH）研究的发现，该研究表明饮食摄入量可以显着降低血压。破折号饮食在高血压患者中特别有效，但我们不知道破折号饮食如何起作用，除了降低血压的影响之外，我们不知道仪表板饮食是否会更广泛地影响经常伴随患者患者的心血管中的结构和功能异常。我们的初步数据强烈支持破折号饮食中断心血管组织中肾素 - 血管紧张素系统的可能性。这些数据和其他数据引起了一种有趣的可能性，即仪表性饮食会产生模仿血管紧张素转化酶（ACE）抑制作用的作用。这种影响将为DM固有的心血管危险因素带来明显的好处。在这项建议中，威廉姆斯博士将在研究培训期间介绍获得的技术和技能，以回答以下问题，即破折号饮食如何影响DM中的心血管功能。该奖项将为（1）巩固他的教学培训，（2）设计，进行和完成一个以患者为导向的研究项目，（3）继续受到其研究领域的领导者的指导。它将为他提供一条明确的途径，以建立心血管内分泌学领域的独立以患者为导向的研究生涯。