Exploratory Center for Vaccinology Research (RMI)

疫苗学研究探索中心 (RMI)

• 批准号: 7393479
• 负责人: Walter A. Orenstein
• 金额: $ 2.36万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-28 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7393479
• 关键词: Adverse event; Advisory Committees; Behavioral Research; Behavioral Sciences; Bioinformatics; Biology, Other; Biometry; Clinical Medicine; Communicable Diseases; Complex; Computing Methodologies; Economic Models; Economics; Educational workshop; Engineering; Epidemiology; Failure; Genetic; Genomics; Goals; Grant; Human; Immune; Immune response; Immunocompromised Host; Immunology; Interdisciplinary Study; Leadership; Link; Methodology; Methods; Microbiology; Modeling; Molecular Immunology; Molecular Profiling; Pathogenesis; Policies; Population Biology; Predisposition; Prevention; Problem Solving; Production; Proteomics; Research; Safety; Science; Science of genetics; Series; Solutions; Structure; Systems Biology; Universities; Vaccine Antigen; Vaccine Research; Vaccines; Work; cost; design; improved; influenza virus vaccine; multidisciplinary; novel strategies; programs; response; vaccine development; vaccinology

DESCRIPTION (provided by applicant): In response to national efforts to develop, improve and deliver vaccines, Emory University requests P-20 grant support for an Exploratory Center for Interdisciplinary Research in Vaccinology (ECIRVE). Vaccines are the most cost-effective prevention known, but the introduction and use of vaccines has become increasingly slowed by a series of obstacles, including delays in identification of candidate antigens for vaccines, incomplete understanding of human immune correlates of protection, limited understanding of the predisposition to vaccine failures or adverse events, difficulty with immune response in the very young, the very old and immunocompromised, incomplete definition of the best strategies for the design of infectious and non-infectious disease vaccines, problems with use and acceptance of vaccines, and problems with vaccine supply and financing. The goals of this application are to develop a comprehensive program to better integrate new quantitative methodologies into vaccinology and to engage multidisciplinary science (genetics, bioinformatics, microbiology and human immunology, biostatistics and analytical epidemiology, behavioral research, economics, population biology, clinical medicine and engineering) in solving significant and complex problems in vaccine development, safety and adverse events, production and supply, acceptance and use. Emory has made an exceptional commitment to vaccine research and has attracted or developed national leaders in basic vaccine sciences (immunology and molecular pathogenesis), vaccine development, vaccine trials, vaccine modeling, vaccine epidemiology and vaccine policy. In the activities of this grant, this outstanding expertise will be combined with key leaders and centers in genetics, bioinformatics, behavioral sciences, economics, engineering, and population biology to plan new solutions to vaccine problems. The first aim will create a multidisciplinary scientific working council of national leaders and center directors to develop novel strategies for problem-solving in vaccinology. The second specific aim will explore how to integrate new quantitative methodologies (genomics, proteomics, systems biology and other computational methodologies) for assessment of vaccine immune responses and reactogenicity, develop better dynamic methods for modeling of vaccine use, and plan integrative models for economic assessment of vaccines. The specific aims will be accomplished through a strong leadership structure, bi-weekly meetings of the multidisciplinary scientific council, yearly workshops; external advisory committee input; and two linked pilot feasibility projects to 1) explore the design and limitations of quantitative methodologies to define molecular signatures of adaptive and innate immune responses to influenza vaccines, and 2) design novel approaches to influenza vaccine policy.

描述（由申请人提供）：

项目成果

Private Pediatric Clinic Characteristics Associated with Influenza Immunization Efforts in the State of Georgia: A Pilot Evaluation.

佐治亚州与流感免疫工作相关的私人儿科诊所特征：试点评估。

• DOI: 10.2174/1874924000801010038
• 发表时间: 2008
• 期刊: The open health services and policy journal
• 作者: Pazol,Karen;Gazmararian,JulieA;Prill,MilaM;O'Malley,EmilyM;Jelks,Deborah;Coleman,MargaretS;Hinman,AlanR;Orenstein,WalterA
• 通讯作者: Orenstein,WalterA

Interdisciplinary epidemiologic and economic research needed to support a universal childhood influenza vaccination policy.

需要跨学科的流行病学和经济研究来支持全民儿童流感疫苗接种政策。

• DOI: 10.1093/epirev/mxj008
• 发表时间: 2006
• 期刊: Epidemiologic reviews
• 影响因子: 5.5
• 作者: Coleman,MargaretS;Washington,MichaelL;Orenstein,WalterA;Gazmararian,JulieA;Prill,MilaM
• 通讯作者: Prill,MilaM

Support for universal childhood vaccination against influenza among private pediatric clinics and public health departments in Georgia.

支持乔治亚州私人儿科诊所和公共卫生部门普及儿童流感疫苗接种。

• DOI: 10.1097/phh.0b013e3181a13951
• 发表时间: 2009
• 期刊: Journal of public health management and practice : JPHMP
• 作者: Pazol,Karen;Prill,MilaM;Gazmararian,JulieA;O'Malley,EmilyM;Jelks,Deborah;Coleman,MargaretS;Hinman,AlanR;Orenstein,WalterA
• 通讯作者: Orenstein,WalterA