Oklahoma Center on American Indian Diabetes Health Disparities

描述（由申请人提供）：俄克拉何马州美国印第安人糖尿病健康差异中心（OCAIDHD）的目的是减少并最终消除因糖尿病而导致的超额死亡率、发病率、生活质量和文化损失。OCAIDHD的主要影响将是糖尿病、孕产妇健康、婴儿死亡率和肥胖。OCAIDHD通过集中多学科、多学院的糖尿病研究人员的专业知识，研究疾病的特定生物、生理、行为和文化压力源，来应对健康差异。由于与俄克拉何马城地区部落间健康委员会（覆盖俄克拉何马州、堪萨斯州和德克萨斯州的所有部落）及其南部平原美洲印第安人流行病学中心建立了伙伴关系，该中心还增加了非大学的优势。OCAIDHD由一名美国印第安人（AI）研究人员指导，这是它与面对前所未有的糖尿病医疗技术的美国印第安人继续忍受健康差距的能力的重要组成部分。中心由四个核心组成：1)管理，2)研究，3)研究培训和教育，4)社区参与和外展。行政核心将作为协调、监督和核算的整体单位。它将由中心PI指导，并有一个由PI、Co-Pi、项目协调员和所有核心董事组成的内部执行委员会。行政核心还将容纳由大学外的AI糖尿病研究人员和领导人组成的外部咨询委员会。研究核心将由该中心的共同负责人指导。研究中心将监督三个完整提案和四个试点项目。交叉主题是减少生物医学和社会文化侮辱对糖尿病最佳管理的倍增效应。完整的提案主题是：1)美国印第安人2型糖尿病先兆子痫的早期标记，2)胰岛素抵抗和糖皮质激素治疗AFs中高发的炎症性疾病，以及3)AI糖尿病的信念和实践：孕产妇护理，婴儿死亡率和依从性。试点项目将探讨这些主题：1)SF-36医疗结果调查：美国印第安人糖尿病人群的验证和文化适应，2)负重活动：美国印第安人糖尿病足健康的联系，3)美国印第安人小学年龄的定期适度运动：稳定的生活活动研究（SAILS），以及4)超重和正常体重的美国印第安儿童的动脉弹性。研究培训/教育核心由OCAIHD合作组织南部平原流行病学中心负责人人工智能指导。该核心的活动将为俄克拉荷马州和堪萨斯州人工智能诊所和医院的护士提供必要的指导和支持，以便在其医疗保健环境中进行实际研究。这项活动的完成将产生一批糖尿病专业的人工智能护士研究人员、一个模型复制课程和一个过程评估。该核心还将协调中心的其他教育活动。社区参与/外展核心由儿童创伤方面的人工智能行为科学专家指导。这个核心将增加和支持本地青年预防糖尿病夏令营开放给所有俄克拉何马州的年龄8-12岁。这个重要的项目将扩大参与者的数量，并收集空腹血脂、血糖、血压、随机血糖、腰围和体重指数的数据。

DESCRIPTION (provided by applicant): The purpose of the Oklahoma Center for American Indian Diabetes Health Disparities (OCAIDHD) is to reduce and eventually eliminate the excess mortality, morbidity, and quality of life and culture lost due to diabetes. The primary impacts of the OCAIDHD will be on diabetes, maternal health, infant mortality, and obesity. The OCAIDHD confronts health disparities by focusing the expertise of a multi-disciplinary, multi-college team of diabetes researchers on specific biological, physiological, behavioral, and cultural stressors of the disease. The Center also has added non-university strengths owing to its partnership with the Oklahoma City Area Inter-tribal Health Board (covering all tribes in Oklahoma, Kansas, and Texas) and its Southern Plains Center on American Indian Epidemiology. That the OCAIDHD is directed by an American Indian (AI) researcher is a significant part of its ability to relate to American Indian people who continue to endure health disparities in the face of unprecedented medical technology for diabetes. The Center is organized by four cores: 1) Administration, 2) Research, 3) Research Training and Education, and 4) Community Engagement and Outreach. The Administrative Core will serve as the overall unit of coordination, supervision, and accounting. It will be directed by the Center PI and have an internal Executive Committee comprised of the PI, Co-Pi, Project Coordinator, and all Core Directors. The Administrative Core will also house the External Advisory Committee comprised of AI diabetes researchers and leaders outside the University. The Research Core will be directed by the Center's Co-PI. The Research Core will oversee three Full Proposals and four Pilot Projects. The cross-cutting theme is reduction of the multiplicative effects of biomedical and sociocultural insults to optimal management of diabetes. Full Proposal topics are 1) Early Markers of Pre-eclampsia in American Indians with Type 2 Diabetes, 2) Insulin Resistance and Glucocorticoid Treatment of Inflammatory Diseases of High Prevalence among AFs, and 3) AI Diabetes Beliefs and Practices: Maternal Care, Infant Mortality, and Adherence. Pilot Projects will explore these topics: 1) SF-36 Medical Outcomes Survey: Validations and Cultural Adaptation in the American Indian Population with Diabetes, 2) Weight Bearing Activity: Links to Diabetic Foot Health in American Indians, 3) Regular Moderate Exercise in Elementary-aged American Indians: Steady Activity in Life Study (SAILS), and 4) Arterial Elasticity in Overweight and Normal Weight American Indian Children. The Research Training/Education Core is directed by an AI who is the head of the Southern Plains Epidemiology Center of the OCAIHD's partner organization. The core's activities will prepare nurses from AI clinics and hospitals in Oklahoma and Kansas with the instruction and support necessary to conduct practical research studies within their health care settings. Completion of this activity will result in a cadre of AI nurse researchers with a specialty in diabetes, a curriculum for model replication, and a process evaluation. This core will also coordinate other education activities of the Center .The Community Engagement/Outreach Core is directed by an AI behavioral science specialist in childhood traumas. This core will augment and support the Native Youth Preventing Diabetes summer camp open to all Oklahoma AI's age 8-12 years. This vital project will expand the number of attendees and collect data on fasting lipids, glucose, blood pressure, random blood glucose, waist circumference, and BMI.