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Fear of Hypoglycemia Survey: Properties, Interpretation and Dissemination

对低血糖的恐惧调查：属性、解释和传播

基本信息

批准号：
7636814
负责人：
Linda Ann Gonder-Frederick
金额：
$ 22.73万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
起止时间：
2008-06-15 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7636814
关键词：
Adolescent Adult Age Anxiety Area Behavior Behavior Therapy Behavioral Bibliography Cataloging Catalogs Child Clinical Clinical Trials Code Communities Country Data Data Analyses Data Files Data Set Databases Development Devices Diabetes Mellitus Drops Ethnic Origin Factor Analysis Family member Frequencies Fright Funding Future Gender Glucose Glycosylated hemoglobin A Goals Home environment Hypoglycemia Injury Insulin Insulin-Dependent Diabetes Mellitus International Internet Investigation Islets of Langerhans Transplantation Laboratories Language Letters Life Measures Medical Methods Monitor Non-Insulin-Dependent Diabetes Mellitus Outcome Outcome Measure Parents Patients Pharmaceutical Preparations Play Procedures Process Property Psychometrics Quality Control Quality of life Questionnaire Designs Questionnaires Race Recording of previous events Research Research Design Research Personnel Resources Role Series Site Source Spouses Structure Subgroup Surveys Symptoms Technology Testing Translating Treatment Protocols United States National Institutes of Health Universities Validity and Reliability Virginia base blood glucose regulation design diabetes control diabetes management experience glucose sensor instrument psychologic psychological distress public health relevance response social statistics theories tool trait web site

项目摘要

DESCRIPTION (provided by applicant): The proposed project is a response to PA-06-151 for secondary data analysis, and will take advantage of a unique set of previously collected data from NIH-funded studies conducted at the University of Virginia (n = > 2500) and other studies around the world (n > 3500) to conduct an in-depth investigation into the Hypoglycemia Fear Survey (HFS) and fear of hypoglycemia (FOH). In diabetes, hypoglycemia can be associated with numerous negative consequences ranging from unpleasant symptoms and social embarrassment to physical injury and even life-threatening situations. For this reason, FOH is considered one of the major psychological barriers to achieving optimal glucose control. Thus, it is critical to study FOH scientifically, understand its impact on quality of life and diabetes control, and reduce its potential negative effect on people living with diabetes. To do this, there must be a way to quantify, or measure, this diabetes-specific form of anxiety. The HFS is a 33-item questionnaire, specifically designed by our research group to measure 1) worry about hypoglycemia and its negative consequences and 2) behaviors to avoid hypoglycemia and its potential effects. The original HFS was designed to measure FOH in adults with type 1 diabetes, but versions were subsequently developed for children with type 1 diabetes, adults with type 2 diabetes, and patients' family members, who may also experience FOH. The HFS has also been translated into at least 12 languages and used in diabetes research in at least 16 different countries, often as an outcome measure in clinical trials of behavioral interventions, diabetes medications, and newly emerging treatments and technologies, including islet cell transplants and continuous glucose sensors. In spite of its widespread utility and use, little is known about the psychometric properties of the HFS, so there is no empirical basis for interpretation of scores or comparisons across patient groups and cultures. The proposed project will create a large, international data set and provide the much-needed opportunity to generate normative HFS data for different patient subgroups, assess the reliability and validity of the HFS, and begin to examine differences in FOH across cultures and global regions. A HypoFear Web portal site will then be developed in order to provide easy access to these psychometric findings to the scientific community and promote empirically-based interpretation of the HFS. This will be an invaluable resource for diabetes researchers and also facilitate the use of the HFS in clinical settings to identify patients with problematic FOH. In addition, the proposed project will take advantage of the unprecedented opportunity provided by these large data sets to explore a number of important hypotheses regarding the development of FOH, and its impact on quality of life, diabetes management, and medical outcome for people living with diabetes. PUBLIC HEALTH RELEVANCE: In people with diabetes, fear of hypoglycemia (FOH) can have a significant negative impact on quality of life and medical outcome, and therefore it is important to study FOH scientifically. The most commonly used measure of FOH around the globe is the Hypoglycemia Fear Survey (HFS), but little is known about what constitutes normal levels of fear in different patient groups, or the reliability and validity of the survey, and this is a major barrier to understanding FOH and how to reduce it. By gathering and analyzing large pre-existing sets of HFS data (over 6,000 surveys from around the world), this project provides a unique opportunity to answer important questions about the HFS and FOH, create a website to provide the diabetes research community with information they need to study FOH, and help people with diabetes reduce the negative impact of FOH on their lives.

描述（由申请人提供）：拟议项目是对 PA-06-151 二次数据分析的回应，并将利用之前从 NIH 资助的弗吉尼亚大学研究 (n = > 2500) 和世界各地其他研究 (n > 3500) 收集的一组独特数据，对低血糖恐惧调查 (HFS) 和低血糖恐惧 (FOH) 进行深入调查。在糖尿病中，低血糖可能会带来许多负面后果，从令人不快的症状和社交尴尬到身体伤害，甚至危及生命的情况。因此，FOH 被认为是实现最佳血糖控制的主要心理障碍之一。因此，科学地研究 FOH，了解其对生活质量和糖尿病控制的影响，并减少其对糖尿病患者的潜在负面影响至关重要。为此，必须有一种方法来量化或测量这种糖尿病特有的焦虑形式。 HFS 是一份包含 33 项的调查问卷，由我们的研究小组专门设计，旨在衡量 1) 对低血糖及其负面后果的担忧，以及 2) 避免低血糖及其潜在影响的行为。最初的 HFS 旨在测量成人 1 型糖尿病患者的 FOH，但随后开发了针对 1 型糖尿病儿童、成人 2 型糖尿病患者以及也可能经历 FOH 的患者家属的版本。 HFS 还被翻译成至少 12 种语言，并在至少 16 个不同国家用于糖尿病研究，通常作为行为干预、糖尿病药物以及新兴治疗和技术（包括胰岛细胞移植和连续血糖传感器）临床试验的结果衡量标准。尽管 HFS 具有广泛的效用和使用，但人们对 HFS 的心理测量特性知之甚少，因此没有经验基础来解释患者群体和文化之间的分数或比较。拟议的项目将创建一个大型国际数据集，并提供急需的机会来为不同患者亚组生成规范的 HFS 数据，评估 HFS 的可靠性和有效性，并开始检查跨文化和全球区域的 FOH 差异。随后将开发一个 HypoFear 门户网站，以便科学界能够轻松获取这些心理测量结果，并促进对 HFS 进行基于经验的解释。这对于糖尿病研究人员来说是宝贵的资源，也有助于在临床环境中使用 HFS 来识别有问题的 FOH 患者。此外，拟议项目将利用这些大数据集提供的前所未有的机会，探索有关 FOH 发展的一些重要假设，及其对糖尿病患者生活质量、糖尿病管理和医疗结果的影响。公共卫生相关性：对于糖尿病患者，对低血糖的恐惧 (FOH) 会对生活质量和医疗结果产生重大负面影响，因此科学地研究 FOH 非常重要。全球最常用的 FOH 测量方法是低血糖恐惧调查 (HFS)，但人们对不同患者群体的正常恐惧水平的构成以及调查的可靠性和有效性知之甚少，这是了解 FOH 以及如何减少 FOH 的主要障碍。通过收集和分析大量现有的 HFS 数据（来自世界各地的 6,000 多项调查），该项目提供了一个独特的机会来回答有关 HFS 和 FOH 的重要问题，创建一个网站，为糖尿病研究界提供研究 FOH 所需的信息，并帮助糖尿病患者减少 FOH 对他们生活的负面影响。