NEW METHODS TO MEASURE AMIDE PROTON RELAXATION DISPERSIONS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 一种新的脉冲序列已被开发，允许测量酰胺质子T1 rho弛豫在更高的灵敏度，更高的精度和更高的有效领域比以前的序列。该序列将用于检测心肌肌钙蛋白C的微秒时间尺度动力学。在比较建立的N15弛豫色散实验将被测量，以及验证的结果。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. A new pulse sequence has been developed that allows the measurement of amide proton T1rho relaxation at higher sensitivity, higher accuracy and higher effective fields than previous sequences. The sequence will be used to detect micorsecond time scale dynamics in cardiac Troponin C. In comarison established N15 relaxation dispersion experiments will be measured as well to verify the results.