NATIONAL BIOMEDICAL COMPUTATION RESOURCE SCIENCE GATEWAY FOR THE TERAGRID

太格网国家生物医学计算资源科学网关

基本信息

  • 批准号:
    7601497
  • 负责人:
  • 金额:
    $ 0.07万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2007
  • 资助国家:
    美国
  • 起止时间:
    2007-08-01 至 2008-07-31
  • 项目状态:
    已结题

项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Begun in 1994, the mission of the National Biomedical Computation Resource (NBCR) is to conduct, catalyze and enable multiscale biomedical research by harnessing advanced computation and data cyberinfrastructure through multidiscipline and multi-institutional integrative research and development activities. We aim to contribute to the development of cyberinfrastructure for multiscale modeling activities. The development of the cyberinfrastructure is driven by multiscale modeling applications, which focuses on scientific research ranging in biological scale from the subatomic, to molecular, cellular, tissue to organ level. Application examples include quantum mechanics modeling with GAMESS, calculation of protein electrostatic potentials with APBS and the finite element toolkit FEtk, protein-ligand docking studies with AutoDock, cardiac systems biology and physiology modeling with Continuity, and molecular visualizations using PMV and visual workflow programming in Vision. Real use cases are used to demonstrate how these multiscale applications may be made available transparently on the grid to researchers in the biomedicine and translational research arena, through integrative projects ranging from the understanding of detailed mechanism of action of HIV protease and integrase, to neuromuscular junction research in myopathy, to heart arrhythmia and failure, and to emerging public health threats, as well as through collaborative projects with other research teams across the world. The adoption of service oriented architecture enables the development of highly reusable software components, and efficiently leverages the international grid development activities. We are in the process of developing an end to end prototype environment, exemplified by the adoption of key components by the Telescience project, that allows existing applications to run transparently on the grid, taking advantage of open source software that provides a portal interface using GridSphere, with transparent GSI authentication using GAMA, a web service wrapper using Opal, a metascheduler using CSF4, a virtual filesystem using Gfarm, and a grid-enabled cluster environment using Rocks. Solutions to complex problems may be developed using workflow tools that coordinate different interoperable services. Large scale problems that can't be solved using local computational resources will need to be made available transparently to our users. This proposal aims to address the specific requirements and add support of transparent access to TeraGrid resources through the TeraGrid Science Gateway program. In addition, we also intend to make such a science gateway available through web services, through the development of ontology and semantic mediation tools such as Pathsys and OntoQuest for data integration and interoperability. NBCR Website URL: http://nbcr.net.
这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者(PI)可能从另一个NIH来源获得了主要资金, 因此可以在其他CRISP条目中表示。所列机构为 研究中心,而研究中心不一定是研究者所在的机构。 从1994年开始,国家生物医学计算资源(NBCR)的使命是通过多学科和多机构的综合研究和开发活动,利用先进的计算和数据网络基础设施,进行,催化和实现多规模的生物医学研究。我们的目标是为多尺度建模活动的网络基础设施的发展做出贡献。网络基础设施的发展是由多尺度建模应用程序驱动的,其重点是从亚原子到分子,细胞,组织到器官水平的生物尺度的科学研究。应用实例包括使用GAMESS进行量子力学建模、使用APBS和有限元工具包FEtk计算蛋白质静电势、使用AutoDock进行蛋白质-配体对接研究、使用Continuity进行心脏系统生物学和生理学建模以及使用PMV和Vision中的可视化工作流编程进行分子可视化。真实的用例用于演示如何在网格上透明地向生物医学和转化研究竞技场的研究人员提供这些多尺度应用程序,通过整合项目,从了解HIV蛋白酶和整合酶的详细作用机制,到肌病中的神经肌肉接头研究,到心律失常和衰竭,以及新出现的公共卫生威胁,以及通过与世界各地其他研究团队的合作项目。采用面向服务的体系结构可以开发出可重用性高的软件组件,并有效地利用了国际网格开发活动。我们正在开发一个端到端的原型环境,Telescience项目采用的关键组件就是一个例子,它允许现有的应用程序透明地在网格上运行,利用开源软件提供了一个使用GridSphere的门户接口,使用GAMA的透明GSI身份验证,使用Opal的Web服务包装器,使用CSF 4的元数据库,使用Gfarm的虚拟文件系统,和一个使用Rocks的网格集群环境。复杂问题的解决方案可以使用协调不同可互操作服务的工作流工具来开发。使用本地计算资源无法解决的大规模问题将需要透明地提供给我们的用户。该提案旨在解决特定需求,并通过TeraGrid科学网关计划增加对TeraGrid资源透明访问的支持。此外,我们还打算通过Web服务,通过开发本体和语义中介工具,如Pathsys和OntoQuest的数据集成和互操作性,使这样的科学网关。NBCR网站URL:http://nbcr.net。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Wilfred Wenfeng Li其他文献

Wilfred Wenfeng Li的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Wilfred Wenfeng Li', 18)}}的其他基金

NBCR SUMMER INSTITUTE: CYBERINFRASTRUCTURE AND MULTISCALE MODELING APPROACHES
NBCR 暑期学院:网络基础设施和多尺度建模方法
  • 批准号:
    8362792
  • 财政年份:
    2011
  • 资助金额:
    $ 0.07万
  • 项目类别:
PROTEIN DATA BANK BIOMEDICAL COMMUNITY SERVICES
蛋白质数据库生物医学社区服务
  • 批准号:
    8362805
  • 财政年份:
    2011
  • 资助金额:
    $ 0.07万
  • 项目类别:
SEQUENCE MOTIF DISCOVERY & SEARCH
序列基序发现
  • 批准号:
    8362791
  • 财政年份:
    2011
  • 资助金额:
    $ 0.07万
  • 项目类别:
RESOURCE CENTERS OF NCRR AT THE BIOPHYSICAL SOCIETY MEETING
生物物理学会会议上的 NCRR 资源中心
  • 批准号:
    8169347
  • 财政年份:
    2010
  • 资助金额:
    $ 0.07万
  • 项目类别:
NATIONAL BIOMEDICAL COMPUTATION RESOURCE SCIENCE GATEWAY FOR THE TERAGRID
太格网国家生物医学计算资源科学网关
  • 批准号:
    8171799
  • 财政年份:
    2010
  • 资助金额:
    $ 0.07万
  • 项目类别:
NATIONAL BIOMEDICAL COMPUTATION RESOURCE SCIENCE GATEWAY FOR THE TERAGRID
太格网国家生物医学计算资源科学网关
  • 批准号:
    7956144
  • 财政年份:
    2009
  • 资助金额:
    $ 0.07万
  • 项目类别:
BIOPHYSICAL SOCIETY MEETING 2005
2005 年生物物理学会会议
  • 批准号:
    7955238
  • 财政年份:
    2009
  • 资助金额:
    $ 0.07万
  • 项目类别:
BIOPHYSICAL SOCIETY MEETING 2005
2005 年生物物理学会会议
  • 批准号:
    7722343
  • 财政年份:
    2008
  • 资助金额:
    $ 0.07万
  • 项目类别:
NATIONAL BIOMEDICAL COMPUTATION RESOURCE SCIENCE GATEWAY FOR THE TERAGRID
太格网国家生物医学计算资源科学网关
  • 批准号:
    7723234
  • 财政年份:
    2008
  • 资助金额:
    $ 0.07万
  • 项目类别:
BIOPHYSICAL SOCIETY MEETING 2005
2005 年生物物理学会会议
  • 批准号:
    7601690
  • 财政年份:
    2007
  • 资助金额:
    $ 0.07万
  • 项目类别:

相似海外基金

WELL-CALF: optimising accuracy for commercial adoption
WELL-CALF:优化商业采用的准确性
  • 批准号:
    10093543
  • 财政年份:
    2024
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Collaborative R&D
Investigating the Adoption, Actual Usage, and Outcomes of Enterprise Collaboration Systems in Remote Work Settings.
调查远程工作环境中企业协作系统的采用、实际使用和结果。
  • 批准号:
    24K16436
  • 财政年份:
    2024
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Unraveling the Dynamics of International Accounting: Exploring the Impact of IFRS Adoption on Firms' Financial Reporting and Business Strategies
揭示国际会计的动态:探索采用 IFRS 对公司财务报告和业务战略的影响
  • 批准号:
    24K16488
  • 财政年份:
    2024
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
ERAMET - Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
ERAMET - 快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10107647
  • 财政年份:
    2024
  • 资助金额:
    $ 0.07万
  • 项目类别:
    EU-Funded
Assessing the Coordination of Electric Vehicle Adoption on Urban Energy Transition: A Geospatial Machine Learning Framework
评估电动汽车采用对城市能源转型的协调:地理空间机器学习框架
  • 批准号:
    24K20973
  • 财政年份:
    2024
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Ecosystem for rapid adoption of modelling and simulation METhods to address regulatory needs in the development of orphan and paediatric medicines
快速采用建模和模拟方法的生态系统,以满足孤儿药和儿科药物开发中的监管需求
  • 批准号:
    10106221
  • 财政年份:
    2024
  • 资助金额:
    $ 0.07万
  • 项目类别:
    EU-Funded
Our focus for this project is accelerating the development and adoption of resource efficient solutions like fashion rental through technological advancement, addressing longer in use and reuse
我们该项目的重点是通过技术进步加快时装租赁等资源高效解决方案的开发和采用,解决更长的使用和重复使用问题
  • 批准号:
    10075502
  • 财政年份:
    2023
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Grant for R&D
Engage2innovate – Enhancing security solution design, adoption and impact through effective engagement and social innovation (E2i)
Engage2innovate — 通过有效参与和社会创新增强安全解决方案的设计、采用和影响 (E2i)
  • 批准号:
    10089082
  • 财政年份:
    2023
  • 资助金额:
    $ 0.07万
  • 项目类别:
    EU-Funded
De-Adoption Beta-Blockers in patients with stable ischemic heart disease without REduced LV ejection fraction, ongoing Ischemia, or Arrhythmias: a randomized Trial with blinded Endpoints (ABbreviate)
在没有左心室射血分数降低、持续性缺血或心律失常的稳定型缺血性心脏病患者中停用β受体阻滞剂:一项盲法终点随机试验(ABbreviate)
  • 批准号:
    481560
  • 财政年份:
    2023
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Operating Grants
Collaborative Research: SCIPE: CyberInfrastructure Professionals InnoVating and brOadening the adoption of advanced Technologies (CI PIVOT)
合作研究:SCIPE:网络基础设施专业人员创新和扩大先进技术的采用 (CI PIVOT)
  • 批准号:
    2321091
  • 财政年份:
    2023
  • 资助金额:
    $ 0.07万
  • 项目类别:
    Standard Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了