COMPUTATIONAL ASPECTS OF VOLATILE ANESTHETIC ACTION AT THE THALAMUS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 尽管已知麻醉剂调节许多神经元的活性， 电压门控和配体门控离子通道，特异性位点和 麻醉作用的机制仍有争议。 的过程 确定如何将单个离子通道的效应整合到 在系统水平上产生麻醉状态是复杂的， 在系统级别上了解什么构成了状态， 全身麻醉可能是多种麻醉剂的混合物， 分开的效果。 计算和理论技术是 对系统神经生物学的重要性日益增加。 使用这些工具，高度 神经行为的特定数学描述可以被模拟， 评价对已知麻醉作用的综合反应， 受体水平 这种方法可能有助于将已知的 在离子通道和整个系统水平上的麻醉作用 行为

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although anesthetics are known to modulate the activity of a number of voltage-gated and ligand-gated ion channels, the specific site(s) and mechanism(s) of anesthetic action remain controversial. The process of determining how effects at individual ion channels are integrated to produce the anesthetic state at the systems level is complicated by limited knowledge of what constitutes that state at the systems level, and the possibility that general anesthesia may be an amalgam of a number of separate effects. Computational and theoretical techniques are tools of increasing importance to systems neurobiology. Using these tools, highly specific mathematical descriptions of neural behavior can be simulated to evaluate the integrated response to known anesthetic effects at the receptor level. This approach may be useful for linking what is known about anesthetic action at the ion channel with overall systems level behavior.