COMPUTATIONAL ASPECTS OF VOLATILE ANESTHETIC ACTION AT THE THALAMUS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 尽管已知麻醉剂可调节多种脑细胞的活动 电压门控和配基门控离子通道，特定部位(S)和 麻醉作用的机制(S)仍存在争议。这一过程 确定单个离子通道上的效果如何集成到 在系统层面产生麻醉状态是复杂而有限的 在系统级别上了解是什么构成了该状态，以及 全身麻醉可能是多种药物的混合体 单独的效果。计算和理论技术是 对系统神经生物学的重要性日益增加。使用这些工具，高度 神经行为的特定数学描述可以模拟为 评估对已知麻醉效果的综合反应 受体水平。这种方法可能有助于将已知的信息联系起来 关于离子通道的麻醉作用与整体系统水平 行为。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Although anesthetics are known to modulate the activity of a number of voltage-gated and ligand-gated ion channels, the specific site(s) and mechanism(s) of anesthetic action remain controversial. The process of determining how effects at individual ion channels are integrated to produce the anesthetic state at the systems level is complicated by limited knowledge of what constitutes that state at the systems level, and the possibility that general anesthesia may be an amalgam of a number of separate effects. Computational and theoretical techniques are tools of increasing importance to systems neurobiology. Using these tools, highly specific mathematical descriptions of neural behavior can be simulated to evaluate the integrated response to known anesthetic effects at the receptor level. This approach may be useful for linking what is known about anesthetic action at the ion channel with overall systems level behavior.