SIGNAL TRANSDUCTION AND PROTEIN PHOSPHORYLATION SYMPOSIUM

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在过去的十年里，随着生物学家认识到综合生物学中的许多问题需要理论，对生物学理论方法的欣赏一直在增加。与此同时，物理学家们也被生物学研究的快速进步所带来的兴奋所吸引。总的来说，信号转导，特别是蛋白激酶，提供了一个极好的和高度动态的模型系统，其中这些理论工具可以应用于单个蛋白质以及由蛋白质磷酸化介导的相互作用的蛋白质网络。决定它们功能的途径、蛋白激酶本身以及蛋白质：蛋白质和蛋白质：配体的相互作用都是高度动态的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Appreciation for theoretical approaches in biology has been increasing over the past decade as biologists have recognized that many problems in integrative biology require theory. At the same time, physicists have been caught up in the excitement generated by rapid advances in biological research. Signal transduction, in general, and protein kinases, in particular, provide an excellent and highly dynamic model system where these theoretical tools can be applied to individual proteins as well as to networks of interacting proteins that are mediated by protein phosphorylations. The pathways, the protein kinases themselves, and the protein:protein and protein:ligand interactions that dictate their function are all highly dynamic.