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DYNAMIC BINDING OF PKA REGULATORY SUBUNIT RI ALPHA

DYNAMIC BINDING OF PKA REGULATORY SUBUNIT RI ALPHA
PKA 调节亚基 RI ALPHA 的动态结合
批准号：
7722373
负责人：
SUSAN S. TAYLOR
金额：
$0.32万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2008
资助国家：
美国
项目状态：
已结题
起止时间：
2008-05-01 至 2009-04-30
来源：
https://reporter.nih.gov/project-details/7722373
关键词：
BindingCatalytic DomainComplexComputer Retrieval of Information on Scientific Projects DatabaseFundingGrantInstitutionPliabilityResearchResearch PersonnelResourcesSourceStructureUnited States National Institutes of Healthcyclic-AMP-dependent protein kinase regulatory subunit RIalphamolecular dynamics

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中文摘要
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英文摘要
This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Recent crystal structures have revealed that regulatory subunit RIalpha of PKA undergoes a dramatic conformational change upon complex formation with the catalytic subunit. Molecular dynamics studies were initiated to elucidate the contributions of intrinsic conformational flexibility and interactions with the catalytic subunit in formation and stabilization of the complex.
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Illuminating the Role of understudied PRKACB Splice Variants in PKA Signaling
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
Lessons Learned from PKA: Assembly of Dynamic Macromolecular Switches
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