SIGNAL TRANSDUCTION AND PROTEIN PHOSPHORYLATION SYMPOSIUM

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在过去的十年里，生物学家们认识到，综合生物学中的许多问题都需要理论来解决，因此对生物学理论方法的赞赏不断增加。与此同时，物理学家们也被生物学研究的快速发展所带来的兴奋所吸引。信号转导，一般来说，和蛋白激酶，特别是，提供了一个优秀的和高度动态的模型系统，这些理论工具可以应用于个别蛋白质以及蛋白质磷酸化介导的相互作用的蛋白质的网络。这些通路、蛋白激酶本身以及决定其功能的蛋白质与蛋白质、蛋白质与配体的相互作用都是高度动态的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Appreciation for theoretical approaches in biology has been increasing over the past decade as biologists have recognized that many problems in integrative biology require theory. At the same time, physicists have been caught up in the excitement generated by rapid advances in biological research. Signal transduction, in general, and protein kinases, in particular, provide an excellent and highly dynamic model system where these theoretical tools can be applied to individual proteins as well as to networks of interacting proteins that are mediated by protein phosphorylations. The pathways, the protein kinases themselves, and the protein:protein and protein:ligand interactions that dictate their function are all highly dynamic.