MOLECULAR DISSECTION OF CONTRACTILE RING ASSEMBLY AND FUNCTION IN C ELEGANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 在有丝分裂中染色体分离之后，这两块DNA必须在物理上分离成子细胞。这种物理细胞分裂是胞质分裂。来自后期纺锤体的信号引发了赤道皮质周围富含丝状肌动蛋白和肌球蛋白II的环的组装。我们正在研究这种收缩环组装的时机和位置的规则，以及它的组成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Following chromosome segregation in mitosis, the two masses of DNA must be physically segregated into the daughter cells. This physical cell division is Cytokinesis. Signals from the anaphase spindle elicit assembly of a ring rich in filamentous actin and myosin II around the equatorial cortex. We are studying the regulation of the timing and placement of the assembly of this contractile ring, as well as its composition.