MOLECULAR DISSECTION OF CONTRACTILE RING ASSEMBLY AND FUNCTION IN C ELEGANS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 中心，不一定是研究者的机构。 在有丝分裂中染色体分离后，两团DNA必须物理分离到子细胞中。 这种物理细胞分裂是胞质分裂。 来自后期纺锤体的信号引起赤道皮质周围富含丝状肌动蛋白和肌球蛋白II的环的组装。 我们正在研究这个收缩环的组装的时间和位置的调节，以及它的组成。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Following chromosome segregation in mitosis, the two masses of DNA must be physically segregated into the daughter cells. This physical cell division is Cytokinesis. Signals from the anaphase spindle elicit assembly of a ring rich in filamentous actin and myosin II around the equatorial cortex. We are studying the regulation of the timing and placement of the assembly of this contractile ring, as well as its composition.