MOLECULAR DISSECTION OF CONTRACTILE RING ASSEMBLY AND FUNCTION IN C ELEGANS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Following chromosome segregation in mitosis, the two masses of DNA must be physically segregated into the daughter cells. This physical cell division is Cytokinesis. Signals from the anaphase spindle elicit assembly of a ring rich in filamentous actin and myosin II around the equatorial cortex. We are studying the regulation of the timing and placement of the assembly of this contractile ring, as well as its composition.