AUTOMATED SPECIMEN HANDLING

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project focuses on the development of a robotic system for loading grids into the specimen stage and subsequently loading the stage into the microscope. Automated methods have been a critical component in the rapid development of high throughput methods for protein crystallography. Our objective is to prototype similar automated sample handling methods for molecular electron microscopy.