METABOLIC FLEXIBILITY IN SEDENTARY LEAN AND OBESE, AND ENDURANCE-TRAINED HUMANS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This aim of this study is to compare the effects of obesity and chronic-endurance training on the ability to use fat as a fuel. A room calorimeter will be used to measure how much fat is used (oxidized) over a 24 h period. In this study, we will compare fat oxidation in non-obese untrained, obese untrained, and endurance-trained individuals. We compare the ability of these groups to increase fat oxidation when 1) exercise is performed; and 2) a high-fat diet is consumed. We believe that ability to adjust fat oxidation will be greatest in endurance athletes, intermediate in non-obese untrained, and lowest untrained obese individuals. This study may lead to a better understanding of how fat is used in obese individuals, and therefore may provide useful information for weight-loss interventions.