METABOLIC FLEXIBILITY IN SEDENTARY LEAN AND OBESE, AND ENDURANCE-TRAINED HUMANS

这个子项目是许多利用 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 这项研究的目的是比较肥胖和长期耐力训练对使用脂肪作为燃料的能力的影响。 将使用室内热量计测量24小时内使用（氧化）的脂肪量。 在这项研究中，我们将比较非肥胖未经训练，肥胖未经训练，和减肥训练的个人脂肪氧化。 我们比较了这些群体在1）进行运动时增加脂肪氧化的能力;和2）食用高脂肪饮食。 我们相信，耐力运动员调节脂肪氧化的能力最强，非肥胖未经训练者居中，未经训练的肥胖者最低。 这项研究可能会更好地了解脂肪在肥胖个体中的作用，因此可能为减肥干预提供有用的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This aim of this study is to compare the effects of obesity and chronic-endurance training on the ability to use fat as a fuel. A room calorimeter will be used to measure how much fat is used (oxidized) over a 24 h period. In this study, we will compare fat oxidation in non-obese untrained, obese untrained, and endurance-trained individuals. We compare the ability of these groups to increase fat oxidation when 1) exercise is performed; and 2) a high-fat diet is consumed. We believe that ability to adjust fat oxidation will be greatest in endurance athletes, intermediate in non-obese untrained, and lowest untrained obese individuals. This study may lead to a better understanding of how fat is used in obese individuals, and therefore may provide useful information for weight-loss interventions.