METABOLIC FLEXIBILITY IN SEDENTARY LEAN AND OBESE, AND ENDURANCE-TRAINED HUMANS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的目的是比较肥胖和慢性耐力训练对利用脂肪作为燃料的能力的影响。室内热量计将被用来测量在24小时内消耗(氧化)了多少脂肪。在这项研究中，我们将比较非肥胖未经训练、肥胖未经训练和耐力训练的个体的脂肪氧化。我们比较了当1)运动和2)食用高脂肪饮食时，这些组增加脂肪氧化的能力。我们认为，耐力运动员调节脂肪氧化的能力最强，未受过训练的非肥胖者居中，未受过训练的肥胖者最低。这项研究可能有助于更好地了解肥胖者是如何利用脂肪的，因此可能为减肥干预提供有用的信息。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This aim of this study is to compare the effects of obesity and chronic-endurance training on the ability to use fat as a fuel. A room calorimeter will be used to measure how much fat is used (oxidized) over a 24 h period. In this study, we will compare fat oxidation in non-obese untrained, obese untrained, and endurance-trained individuals. We compare the ability of these groups to increase fat oxidation when 1) exercise is performed; and 2) a high-fat diet is consumed. We believe that ability to adjust fat oxidation will be greatest in endurance athletes, intermediate in non-obese untrained, and lowest untrained obese individuals. This study may lead to a better understanding of how fat is used in obese individuals, and therefore may provide useful information for weight-loss interventions.