METABOLIC AND PHYSIOLOGIC STABILITY FOLLOWING WEIGHT LOSS

减肥后的代谢和生理稳定性

• 批准号: 7719454
• 负责人: Edward L Melanson
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719454
• 关键词: Blood; Body Weight; Body Weight decreased; Computer Retrieval of Information on Scientific Projects Database; Depressed mood; Dietitian; Funding; Grant; Hormones; Institution; Lipids; Maintenance; Measurement; Measures; Metabolic; Physiological; Proteins; Rate; Research; Research Personnel; Resources; Source; Supervision; Time; United States National Institutes of Health; Week; Weight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will determine how it long it takes for metabolic rate to return to normal after weight loss. When people lose weight, their metabolic rate is reduced, but after some time, it appears to return to normal, although this issue is still debated. In this study, we will measure metabolic rate several times during the first few weeks after a target of 10% weight loss has been achieved. Subjects will remain under supervision of the GCRC dietitians for the next 3 months, and during this period, we will help them maintain their weight loss and measure metabolic rate at 1 month intervals. This will help us answer the question of whether metabolic rate remains depressed, and if not, how long it takes to return to normal. We will also measure selected hormones, proteins, and lipids in the blood during this period to determine if any of these variables are altered during the prolonged period of weight loss maintenance. We will ask subjects to return 1 year later and repeat the experiment, and we will also measure their body weight. We will then look to see if any of the measurements we obtained during the early portion of weight-loss maintenance predict how much weight is regained.

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构为 中心，但不一定是研究者所在的机构。 这项研究将确定减肥后代谢率恢复正常需要多长时间。 当人们减肥时，他们的代谢率会降低，但一段时间后，它似乎会恢复正常，尽管这个问题仍然存在争议。 在这项研究中，我们将在达到10%体重减轻目标后的前几周内多次测量代谢率。 受试者将在接下来的3个月内接受GCRC营养师的监督，在此期间，我们将帮助他们保持体重减轻，并每隔1个月测量代谢率。 这将帮助我们回答代谢率是否保持低迷的问题，如果不是，需要多长时间才能恢复正常。 我们还将在此期间测量血液中选定的激素，蛋白质和脂质，以确定这些变量中的任何一个是否在长时间的减肥维持期间发生变化。 我们会要求受试者一年后返回并重复实验，我们还会测量他们的体重。 然后，我们将看看我们在减肥维持的早期阶段获得的任何测量结果是否可以预测体重会恢复多少。