METABOLIC AND PHYSIOLOGIC STABILITY FOLLOWING WEIGHT LOSS

减肥后的代谢和生理稳定性

• 批准号: 7719454
• 负责人: Edward L Melanson
• 金额: $ 0.14万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-04-01 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7719454
• 关键词: Blood; Body Weight; Body Weight decreased; Computer Retrieval of Information on Scientific Projects Database; Depressed mood; Dietitian; Funding; Grant; Hormones; Institution; Lipids; Maintenance; Measurement; Measures; Metabolic; Physiological; Proteins; Rate; Research; Research Personnel; Resources; Source; Supervision; Time; United States National Institutes of Health; Week; Weight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will determine how it long it takes for metabolic rate to return to normal after weight loss. When people lose weight, their metabolic rate is reduced, but after some time, it appears to return to normal, although this issue is still debated. In this study, we will measure metabolic rate several times during the first few weeks after a target of 10% weight loss has been achieved. Subjects will remain under supervision of the GCRC dietitians for the next 3 months, and during this period, we will help them maintain their weight loss and measure metabolic rate at 1 month intervals. This will help us answer the question of whether metabolic rate remains depressed, and if not, how long it takes to return to normal. We will also measure selected hormones, proteins, and lipids in the blood during this period to determine if any of these variables are altered during the prolonged period of weight loss maintenance. We will ask subjects to return 1 year later and repeat the experiment, and we will also measure their body weight. We will then look to see if any of the measurements we obtained during the early portion of weight-loss maintenance predict how much weight is regained.

这个子项目是众多研究子项目之一