Measuring free-living energy expenditure using direct calorimetry

使用直接量热法测量自由生活的能量消耗

• 批准号: 8723167
• 负责人: Edward L Melanson
• 金额: $ 51.27万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8723167
• 关键词: Affect; Age; Area; Behavior; Body Composition; Burn injury; Calories; Calorimetry; Characteristics; Clinical; Clinical Research; Clothing; Data; Devices; Energy Metabolism; Exercise; Feedback; Flow-It; Goals; Gold; Heart Rate; Heat Losses; Heating; Hour; Human; Indirect Calorimetry; Individual; Label; Life; Measurement; Measures; Membrane; Monitor; Obesity; Outcome; Physical activity; Physiological; Pilot Projects; Research; Signal Transduction; Sum; Sweat; Technology; Temperature; Testing; Thermogenesis; Time; Translating; Variant; Water; Weight; Weight maintenance regimen; base; clinical practice; cost; design; evaporation; improved; innovation; instrument; meetings; meter; novel strategies; public health research; research study; sex; standard measure

DESCRIPTION (provided by applicant): Current approaches to measuring total daily energy expenditure (TDEE) in free-living individuals are limited by cost, accuracy, and lack of sensitivity to specific activities. Accurate, reliable, and low cost approaches for measuring TDEE are needed not only to improve clinical outcomes (e.g. weight management), but also to meet public health research objectives. In humans, EE is proportional to total heat loss, which is the sum of conductive, convective, radiant and evaporative heat flows, and measurement of heat loss is the basis of direct calorimetry. However, it has not been possible to accurately measure all forms of heat flux in free-living humans, particularly evaporative heat loss, which can be a substantial component of total heat production. A recently developed heat flow gauge with the capacity to measure all forms of heat flux has shown promise in proof of concept trials and pilot studies, but its accuracy in measuring TDEE has not yet been thoroughly tested. Moreover, how accuracy is affected by factors such as clothing, ambient temperature, and adiposity has not been studied. The objectives of the proposed research are to a) refine the measurement of TDEE based on total heat flux by determining how factors such as clothing, ambient temperature, age, sex, and body composition influence accuracy; b) compare the accuracy of this approach against the criterion measurements of DLW and whole-room indirect calorimetry; and c) compare the accuracy against a similar instrument that measures heat flux, but is not capable of directly measuring the evaporative component. The proposed research is innovative because it will test the accuracy of an approach that is based on a physiological signal (heat production) which is directly proportional to EE. In addition to accurately measuring TDEE, identifying and distinguishing different types of physical activity is an important goal of physical activity related research, but the capacity to do so is limited. Thus, an additional goal of the proposed research is to determine if measurement of changes in heat flux can be used to identify EE in specific bouts of activity and to differentiate between upper body and lower body activity. The proposed studies will permit refinement of a technology that will have major impact in both clinical practice and research. This new approach will potentially provide substantive improvements in the measurement of TDEE in free-living humans and in the assessment of physical activity and the associated energy cost.

描述（由申请人提供）：目前测量自由生活个体每日总能量消耗（TDEE）的方法受到成本，准确性和对特定活动缺乏敏感性的限制。准确、可靠和低成本的TDEE测量方法不仅需要改善临床结果（例如体重管理），而且还需要满足公共卫生研究目标。在人体中，EE与总热损失成比例，总热损失是传导、对流、辐射和蒸发热流的总和，热损失的测量是直接量热法的基础。然而，尚不可能准确测量自由生活的人类中所有形式的热通量，特别是蒸发热损失，它可能是总产热的重要组成部分。最近开发的热流计能够测量所有形式的热通量，在概念验证试验和试点研究中显示出了希望，但其测量TDEE的准确性尚未得到彻底测试。此外，准确性如何受到服装、环境温度和肥胖等因素的影响尚未研究。拟议研究的目标是：a）通过确定服装、环境温度、年龄、性别和身体成分等因素如何影响准确性，完善基于总热通量的TDEE测量; B）将该方法的准确性与DLW和全室间接热量测量的标准测量进行比较;以及c）将精度与测量热通量但不能直接测量蒸发分量的类似仪器进行比较。拟议的研究是创新的，因为它将测试的方法，是基于一个生理信号（产热），这是直接成比例的EE. In准确测量TDEE，识别和区分不同类型的身体活动是一个重要的目标，身体活动相关的研究，但这样做的能力是有限的。因此，拟议研究的另一个目标是确定热通量变化的测量是否可用于识别特定活动中的EE，并区分上半身和下半身活动。拟议的研究将允许改进一项技术，这将对临床实践和研究产生重大影响。这种新方法将有可能在自由生活的人类TDEE的测量和身体活动和相关能源成本的评估方面提供实质性的改进。

项目成果

One size fits all electronics for insole-based activity monitoring.

一种尺寸适合所有用于鞋垫活动监测的电子设备。

• DOI: 10.1109/embc.2017.8037627
• 发表时间: 2017
• 期刊: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
• 作者: Hegde,Nagaraj;Bries,Matthew;Melanson,Edward;Sazonov,Edward
• 通讯作者: Sazonov,Edward

3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement (University of Massachusetts, Amherst, USA, June 17-19, 2013).

第三届身体活动和运动动态监测国际会议（美国阿默斯特马萨诸塞大学，2013 年 6 月 17-19 日）。

• DOI: 10.1088/0967-3334/35/11/2179
• 发表时间: 2014
• 期刊: Physiological measurement
• 影响因子: 3.2
• 作者: Stansfield,Ben;Clemes,Stacy;John,Dinesh;Meijer,Kenneth;Melanson,Ed;Rowlands,Alex;Staudenmayer,John
• 通讯作者: Staudenmayer,John