THE EFFECTS OF SHORT-TERM OVERFEEDING ON INTAKE

短期过量喂养对摄入量的影响

• 批准号: 7604381
• 负责人: Marc-Andre Cornier
• 金额: $ 3.13万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604381
• 关键词: Biological; Biological Process; Biology; Calories; Computer Retrieval of Information on Scientific Projects Database; Diet; Eating; Energy Intake; Environment; Environmental Risk Factor; Feeding behaviors; Funding; Future; Goals; Grant; Hunger; Individual; Institution; Intake; Measures; Obesity; Physical activity; Prevalence; Public Health; Rate; Regulation; Research; Research Personnel; Research Project Grants; Resistance; Resources; Risk; Satiation; Source; System; Testing; United States; United States National Institutes of Health; Weight; Weight Gain; day; desire; energy balance; insight

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The goal of the proposed research project is to gain a better understanding of the effects of short-term overfeeding on intake and feeding behavior in individuals who are prone to obesity as compared to individuals who appear to be resistant to obesity in our current environment of excessive intake and reduced activity. Obesity is a serious and growing public health problem in the United States. The biological processes that underlie this increasing prevalence of obesity have not been clearly defined but likely involve faulty interactions between environmental factors (excess food intake and reduced physical activity) and biological systems of weight regulation in individuals who are genetically "at risk." Individuals who are genetically predisposed to being lean in our current environment may be able to sense and respond to excess caloric intake more rapidly and accurately than those predisposed to obesity. As compared to obese prone individuals, obese resistant individuals will sense the positive energy balance associated with 3 days of overfeeding more effectively as manifested by higher ratings of satiety, lower ratings of hunger and desire to eat and reduced spontaneous food intake following overfeeding. It is hypothesized that obese resistant individuals will respond to 3 days of overfeeding by sensing the excess calories more effectively than obese prone individuals, as manifested by higher ratings of satiety, lower ratings of hunger and desire to eat and reduced spontaneous food intake following overfeeding. The end result is that these mechanisms will protect lean individuals from excessive weight gain. To test these ideas, intake studies on obese resistant and obese prone individuals after a control diet and after a 3-day period of overfeeding (50% excess caloric intake per day) are proposed. Specifically, studies on the effects of overfeeding on the ad-libitum energy intake and measures of hunger and satiety will be performed. These studies will provide insight into the biology that predisposes to weight gain and regain and will lay the groundwork for future studies of the abnormalities that exist in obese and pre-obese individuals.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 拟议研究项目的目标是更好地了解短期过度喂养对容易肥胖的个体的摄入量和喂养行为的影响，与在我们当前摄入过多和活动减少的环境中似乎对肥胖具有抵抗力的个体相比。 肥胖是美国一个严重且日益严重的公共卫生问题。 导致肥胖日益流行的生物过程尚未明确定义，但可能涉及环境因素（过量食物摄入和体力活动减少）与遗传“危险”个体的体重调节生物系统之间的错误相互作用。 在我们当前的环境中，遗传上倾向于瘦的人可能比那些倾向于肥胖的人更快速、更准确地感知和应对过量的热量摄入。 与易于肥胖的个体相比，抗肥胖个体将更有效地感受到与 3 天的过度喂养相关的正能量平衡，表现为较高的饱腹感、较低的饥饿度和进食欲望以及过度喂养后自发食物摄入量的减少。 据推测，抗肥胖个体会比易肥胖个体更有效地感知过量热量，从而对 3 天的过度喂养做出反应，表现为饱腹感较高、饥饿感和进食欲望较低以及过度喂养后自发食物摄入量减少。 最终结果是，这些机制将保护瘦人免于体重过度增加。 为了检验这些想法，建议对抗肥胖和易肥胖个体在控制饮食后和 3 天的过度喂养（每天摄入过量 50% 的热量）后进行摄入研究。 具体来说，将研究过度喂养对随意能量摄入的影响以及饥饿和饱腹感的测量。 这些研究将深入了解导致体重增加和恢复的生物学原理，并为未来研究肥胖和肥胖前期个体中存在的异常奠定基础。