The Effects of Resistance Training on Appetite Regulation

项目总结 肥胖是一个重大的公共卫生问题，因为不良共病健康后果的风险增加。 以及与之相关的经济压力。体重减轻是指超重/肥胖的人，但不幸的是 由于生物行为的原因，减肥和保持减肥是具有挑战性的，而且往往不成功 促进体重恢复的适应。有必要更好地了解潜在的机制 调整能源平衡，以便制定更有效和更有针对性的战略。神经成像 技术，特别是功能磁共振成像(FMRI)最近被用来揭示 关于肥胖和减肥中食物摄入行为的中枢-外周调节的信息。锻炼是一种 一种有希望的强化减肥和减肥维持的候选方案，因为它影响到两种能量 支出和能量摄入量。然而，关于锻炼方式的研究还不够充分，尤其是 阻力训练影响超重/肥胖成年人的食欲和能量摄入调节。此外， 运动对能量摄取和消耗的影响，因此身体质量在个体之间有很大的差异。 很可能，食欲调节的生物行为指数的差异可以解释这种差异。这个 拟议项目的总体目标是确定为期12周的阻力训练干预的效果 神经、激素和行为指标的食欲调节和能量摄入以前久坐， 超重/肥胖的成年人。为实现这一目标，将在事前和事后完成以下措施- 干预：1)大脑相关区域对视觉享乐和非享乐食物提示的神经元反应 有食物摄取和奖励处理，以及内在的休息状态网络；2)食欲评级；3)食欲- 相关多肽；4)与进食有关的行为；5)自由能量摄入。次要目标是比较 代偿者(脂肪质量减少率最低的三分位数)和非补偿者(那些处于 脂肪质量损失的最高三分之三)，以便开始识别预测反应变化的因素 观察体重和食欲相关指数对运动干预的反应。最后，评选结果 目前的建议将与我们实验室正在进行的一项评估食欲的试验的结果进行比较 12周有氧运动和非运动控制条件下的调节和能量摄入 相似群体(ADA 1-14-TS-07)。这将提供关于锻炼和/或减肥方式如何 不同程度地影响食欲指数和能量摄入调节指数。总体而言，这项研究将提供重要的 关于运动，特别是抵抗力训练对复杂的神经内分泌和 控制食物摄入量和能量平衡的行为交互作用，以及补偿器和 非补偿器。这些知识对于制定有效和个性化的体重至关重要。 肥胖管理的维持治疗策略和临床指南。

PROJECT SUMMARY Obesity is a significant public health concern due to the increased risk of adverse co-morbid health outcomes and associated economic strain. Weight loss is indicated for overweight/obese individuals, but unfortunately weight loss and maintenance of weight loss are challenging and often unsuccessful due to bio-behavioral adaptations which promote weight regain. There is a need to better understand the mechanisms underlying energy balance regulation so that more effective and targeted strategies can be developed. Neuroimaging techniques, specifically functional magnetic resonance imaging (fMRI), have recently been utilized to uncover information on the central-peripheral regulation of food intake behaviors in obesity and weight loss. Exercise is a promising candidate for enhanced weight loss and weight loss maintenance as it influences both energy expenditure and energy intake. However, there is insufficient research on how exercise modality, particularly resistance training, influences appetite and energy intake regulation in overweight/obese adults. Furthermore, the effects of exercise on energy intake and expenditure, and thus body mass vary greatly between individuals. It is likely that differences in the bio-behavioral indices of appetite regulation can explain this variability. The overall goal of the proposed project is to determine the effects of a 12-week resistance training intervention on neuronal, hormonal, and behavioral indices of appetite regulation and energy intake in previously sedentary, overweight/obese adults. To achieve this goal, the following measures will be completed pre- and post- intervention: 1) neuronal response to visual hedonic and non-hedonic food cues in brain regions associated with food-intake and reward processing, and intrinsic resting state networks; 2) appetite ratings; 3) appetite- related peptides; 4) eating-related behaviors; and 5) ad libitum energy intake. A secondary goal is to compare outcomes between Compensators (those in lowest tertile of fat mass loss) and Non-Compensators (those in the highest tertile of fat mass loss) in order to begin to identify factors which predict the response variation seen with body mass and appetite-related indices in response to exercise interventions. Finally, results of the present proposal will be compared to findings from an ongoing trial in our laboratory evaluating appetite regulation and energy intake in response to a 12-week aerobic exercise and non-exercise control condition in a similar population (ADA 1-14-TS-07). This will provide insight on how exercise and/or weight-loss modality may differentially influence indices of appetite and energy intake regulation. Overall, this study will provide important information on the effects of exercise, particularly resistance training, on the complex neuro-endocrine and behavioral interactions controlling food intake and energy balance, and differences between Compensators vs. Non-Compensators. This knowledge will be crucial to the development of effective and individualized weight maintenance treatment strategies and clinical guidelines for obesity management.