The Effects of Resistance Training on Appetite Regulation

阻力训练对食欲调节的影响

• 批准号: 9753219
• 负责人: Marc-Andre Cornier
• 金额: $ 23.33万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2021-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9753219
• 关键词: Aerobic Exercise; Affect; Appetite Regulation; Attention; Attenuated; Behavior; Behavioral; Behavioral Mechanisms; Biological; Body Weight decreased; Brain; Brain region; Clinical; Comorbidity; Complex; Cues; Data; Desire for food; Development; Eating; Economics; Educational Intervention; Energy Intake; Energy Metabolism; Exercise; Fatty acid glycerol esters; Feeding behaviors; Food; Food Energy; Food Intake Regulation; Functional Magnetic Resonance Imaging; Goals; Guidelines; Health; High Prevalence; Hormonal; Hunger; Hypothalamic structure; Impulsivity; Individual; Insula of Reil; Intervention; Investigation; Knowledge; Laboratories; Maintenance; Measures; Modality; Motivation; Neurons; Neurosecretory Systems; Obesity; Outcome; Overweight; Participant; Pathway interactions; Peptides; Peripheral; Population; Prefrontal Cortex; Process; Public Health; Regulation; Research; Rest; Rewards; Risk; Satiation; Self Efficacy; Techniques; Variant; Visual; Weight; Weight Gain; Weight maintenance regimen; adult obesity; attenuation; biobehavior; craving; energy balance; exercise intervention; exercise training; ghrelin; glucagon-like peptide 1; hedonic; improved; indexing; insight; mode of exercise; neuroimaging; obesity management; post intervention; predicting response; pressure; response; reward processing; sedentary; strength training; targeted treatment; therapy development; treatment strategy; weight maintenance

PROJECT SUMMARY Obesity is a significant public health concern due to the increased risk of adverse co-morbid health outcomes and associated economic strain. Weight loss is indicated for overweight/obese individuals, but unfortunately weight loss and maintenance of weight loss are challenging and often unsuccessful due to bio-behavioral adaptations which promote weight regain. There is a need to better understand the mechanisms underlying energy balance regulation so that more effective and targeted strategies can be developed. Neuroimaging techniques, specifically functional magnetic resonance imaging (fMRI), have recently been utilized to uncover information on the central-peripheral regulation of food intake behaviors in obesity and weight loss. Exercise is a promising candidate for enhanced weight loss and weight loss maintenance as it influences both energy expenditure and energy intake. However, there is insufficient research on how exercise modality, particularly resistance training, influences appetite and energy intake regulation in overweight/obese adults. Furthermore, the effects of exercise on energy intake and expenditure, and thus body mass vary greatly between individuals. It is likely that differences in the bio-behavioral indices of appetite regulation can explain this variability. The overall goal of the proposed project is to determine the effects of a 12-week resistance training intervention on neuronal, hormonal, and behavioral indices of appetite regulation and energy intake in previously sedentary, overweight/obese adults. To achieve this goal, the following measures will be completed pre- and post- intervention: 1) neuronal response to visual hedonic and non-hedonic food cues in brain regions associated with food-intake and reward processing, and intrinsic resting state networks; 2) appetite ratings; 3) appetite- related peptides; 4) eating-related behaviors; and 5) ad libitum energy intake. A secondary goal is to compare outcomes between Compensators (those in lowest tertile of fat mass loss) and Non-Compensators (those in the highest tertile of fat mass loss) in order to begin to identify factors which predict the response variation seen with body mass and appetite-related indices in response to exercise interventions. Finally, results of the present proposal will be compared to findings from an ongoing trial in our laboratory evaluating appetite regulation and energy intake in response to a 12-week aerobic exercise and non-exercise control condition in a similar population (ADA 1-14-TS-07). This will provide insight on how exercise and/or weight-loss modality may differentially influence indices of appetite and energy intake regulation. Overall, this study will provide important information on the effects of exercise, particularly resistance training, on the complex neuro-endocrine and behavioral interactions controlling food intake and energy balance, and differences between Compensators vs. Non-Compensators. This knowledge will be crucial to the development of effective and individualized weight maintenance treatment strategies and clinical guidelines for obesity management.

项目摘要 肥胖是一个重要的公共卫生问题，因为不良共病健康结果的风险增加 以及相关的经济压力。减肥是指超重/肥胖的人，但不幸的是， 由于生物行为原因，减肥和维持减肥具有挑战性，并且通常不成功 促进体重恢复的适应性。有必要更好地了解其背后的机制， 能源平衡调节，以便制定更有效和更有针对性的战略。神经影像 技术，特别是功能性磁共振成像（fMRI），最近已被用来揭示 关于肥胖和减肥中食物摄入行为的中枢-外周调节的信息。锻炼是 一个有前途的候选人增强减肥和减肥维持，因为它影响双方的能量 消耗和能量摄入。然而，关于运动方式，特别是 阻力训练影响超重/肥胖成年人的食欲和能量摄入调节。此外，委员会认为， 运动对能量摄入和消耗的影响，以及因此对体重的影响在个体之间差异很大。 食欲调节的生物行为指标的差异可能可以解释这种变异性。的 拟议项目的总体目标是确定为期12周的阻力训练干预对 神经元，激素和食欲调节和能量摄入的行为指数， 超重/肥胖的成年人。为实现这一目标，将在2010年前后完成以下措施： 干预：1）大脑相关区域对视觉享乐和非享乐食物线索的神经元反应 与食物摄入和奖励处理，以及内在的静息状态网络; 2）食欲评级; 3）食欲- 相关肽; 4）进食相关行为;和5）随意能量摄入。第二个目标是比较 补偿者（脂肪量减少最低三分位数的人）和非补偿者（ 脂肪量减少的最高三分位数），以便开始识别预测反应变化的因素 运动干预后的体重和食欲相关指数。最后， 目前的建议将与我们实验室正在进行的一项评估食欲的试验结果进行比较 调节和能量摄入，以响应12周的有氧运动和非运动控制条件， 相似人群（ADA 1-14-TS-07）。这将提供关于锻炼和/或减肥方式如何可以 不同的影响食欲和能量摄入调节指数。总的来说，这项研究将提供重要的 关于运动，特别是阻力训练对复杂的神经内分泌和 控制食物摄入和能量平衡的行为相互作用，以及补偿者与 非补偿器。这方面的知识将是至关重要的发展有效和个性化的重量 维持治疗策略和肥胖管理的临床指南。