TRTMNT INTRUPTN AMNG SBJTS ON POTENT ANTIRTROVIRAL THRPY W/IN 16 DYS OF DIAGNSS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这项研究的主要目的是测试一种疫苗，看看它是否能对抗艾滋病毒感染。这种研究疫苗是为那些在感染艾滋病毒后不久就开始服用抗艾滋病毒药物的人准备的。我们正在寻找几周前(急性感染)或几个月前(最近感染)感染的人。 这项研究的第一个目标是看看如果受试者接种了研究疫苗，然后停止服用抗艾滋病毒药物，他们血液中的艾滋病毒含量会发生什么。我们还不知道研究疫苗是否会对血液中的艾滋病毒数量产生影响。这项研究的第二个目标是看看研究疫苗对艾滋病毒携带者是否安全。如果研究疫苗有效，接种疫苗的人可能能够服用更少的抗艾滋病毒药物。 疫苗帮助人体免疫系统对抗艾滋病毒等感染。参加这项研究的人将接受含有研究疫苗或疫苗安慰剂的注射(注射)。这项研究的安慰剂是一种没有疫苗、药物或药物的水和盐溶液。我们将观察接受研究疫苗或安慰剂的人的免疫系统是否有不同的反应。 我们将通过比较接受疫苗或安慰剂并在24周内停止服用抗艾滋病毒药物的人血液中HIV的数量(HIV病毒载量)来研究免疫系统。许多人，但不是所有人，将接受研究疫苗或安慰剂，如本研究所述。这项研究中的许多人，但不是所有人，将能够在24周内停止服用抗艾滋病毒药物。那些既能接种疫苗又能停用抗艾滋病毒药物的人将接受病毒载量检测。研究中的疫苗或安慰剂将通过在靠近肩膀的一只上臂注射(注射)给人们。安慰剂类似于研究疫苗，但没有活性物质。该研究疫苗被称为MRKAd5 HIV-1 Gag/Poll/nef疫苗。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The main purpose of this study is to test a vaccine to see if it fights HIV infection. The study vaccine is for people who started anti-HIV drugs soon after they were infected with HIV. We are looking for people who were infected just a few weeks ago (acute infection) or a few months ago (recent infection). The first goal of this study is to see what happens to the amount of HIV in subjects' blood if they receive the study vaccine and then stop taking their anti-HIV drugs. We do not yet know if the study vaccine will make a difference on the amount of HIV in the blood. The second goal of the study is to see if the study vaccine is safe for people who have HIV. If the study vaccine works, people who receive it may be able to take fewer anti-HIV drugs. Vaccines help the body's immune system fight infections such as HIV. People who join this study will receive injections (shots) that contain either the study vaccine or a vaccine placebo. The placebo for this study is a water and salt solution that has no vaccine, medicine, or drugs. We will see if the immune system responds differently in people who receive the study vaccine or the placebo. We will study the immune system by comparing the amount of HIV in the blood (HIV viral load) in people who receive either the vaccine or the placebo and who then stop taking their anti-HIV drugs for 24 weeks, about six months. Many people, but not all, will receive either the study vaccine or placebo as described for this study. Many people on this study, but not all, will be able to stop their anti-HIV drugs for 24 weeks. Those who can both receive the vaccine and stop their anti-HIV drugs will have their viral load measured. The study vaccine or placebo will be given to people by injections (shots) in one upper arm near the shoulder. The placebo is like the study vaccine but without the active material. The study vaccine is called MRKAd5 HIV-1 gag/pol/nef vaccine.