INSULIN RESISTANCE IN HYPERANDROGENEMIC WOMEN

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 多囊卵巢综合征（PCOS）是绝经前妇女最常见的内分泌疾病之一，影响5-10%的这一人群。 它有大量的生殖和代谢疾病。 PCOS的病因仍然未知，但有令人信服的证据表明，这种疾病存在遗传易感性。 本项目支持NIH/NICHD U 54 HD 034449的目标2。 该项目专门检验了胰岛素抵抗可能决定高雄激素血症和正常月经周期女性生殖表型表达（即月经不规律和可能的无排卵）的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Polycystic ovary syndrome (PCOS) is among the most common endocrine disorders of premenopausal women, affecting 5-10% of this population. It has substantial reproductive and metabolic morbidities. The etiology of PCOS remains unknown, but there is compelling evidence to indicate that there is a genetic susceptibility to this disorder. This project supports Aim 2 of NIH/NICHD U54 HD034449. This project specifically tests the hypothesis that insulin resistance may determine reproductive phenotypic expression (i.e. irregular menses and possibly anovulation) in women with hyperandrogenemia and normal menstrual cycles.