CHILDREN'S MEMORIAL FOOD ALLERGY STUDY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 食物过敏的原因在很大程度上是未知的。 然而，根据现有的流行病学，临床和实验室研究，食物过敏似乎是一个复杂的性状，可能受到产前和产后环境因素以及遗传因素的影响。 本研究的总体目标是更好地了解食物过敏的自然史，产前和产后环境因素以及遗传因素在食物过敏的发展和预后中的作用。 我们还希望确定新的血清和遗传生物标志物，以更准确地确定食物过敏亚型，预后和治疗靶点。 我们建议进行一项多地点的观察性研究，目的是更好地了解食物的自然历史和病因 通过分析和整合来自三个互补研究队列的数据， 具体而言，我们希望： 1. 前瞻性随访波士顿医学中心（BMC）现有的出生队列，约3，000对母婴。 波士顿出生队列非常适合评估产前和产后环境因素、易感基因和脐带血生物标志物对儿童食物过敏发展和预后的影响。 现场数据收集程序与现行CMH IRB方案# 2004-12324“BMC儿童健康研究”相似，不同之处在于我们希望添加（1）问卷和病历摘要中关于食物过敏的其他问题;以及（2）皮肤点刺试验和测量与食物过敏相关的其他生物标志物。 “BMC儿童健康研究”也获得了波士顿大学医学中心的IRB批准。 2. 前瞻性随访现有的约2000对6岁及以上双胞胎（4,000例受试者）的中国双胞胎队列;中国双胞胎队列提供了估计食物过敏遗传度（环境和遗传因素的相对作用）的理想工具。 现场数据收集程序与现行CMH IRB方案# 2005-12438“儿童代谢综合征流行病学”相似，不同之处在于我们希望在问卷中添加（1）关于食物过敏的其他问题;（2）皮肤点刺试验和测量食物过敏的其他生物标志物。 “儿童代谢综合征流行病学”也获得了中国安徽医科大学的IRB批准 3. 在儿童纪念医院建立一个前瞻性的临床队列，包括约450个核心家庭，至少有一个孩子有食物过敏（病例家庭）和约450个对照家庭没有任何食物过敏。 芝加哥临床队列可以作为一个独立的人群来验证波士顿和中国队列的研究结果，并为未来的转化研究奠定基础。 现场数据收集程序包括：（1）问卷访谈;（2）病历审查;（3）静脉血样采集和食物过敏生物标志物检测;（4）皮肤点刺试验;（5）6岁或以上研究受试者的肺功能检测。 这项研究的独特优势在于，它将作为一项深入的横向和纵向调查，对已建立的和新的食物过敏表型之间的相互关系和时间关系进行研究，并将探讨环境和遗传因素在食物过敏的发展和预后中的作用。 这项研究提供了一个整合三个互补研究队列数据的机会。从科学的角度来看，理想的做法是利用一个种群进行发现，并利用另一个种群进行确认。 这三个队列将共同创建一个独特而丰富的数据库，用于开发新的研究计划和竞争NIH和其他校外赠款。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The causes of food allergy are largely unknown. However, based on available epidemiological, clinical, and laboratory research, food allergy appears to be a complex trait and may be affected by both prenatal and postnatal environmental factors as well as genetic factors. The overall goal of this study is to better understand natural history of food allergy and the role of prenatal and postnatal environmental factors as well as genetic factors in the development and prognosis of food allergy. We also hope to identify novel serum and genetic biomarkers for more accurate means of defining food allergy subtypes, prognosis, and therapeutic targets. We propose to conduct a multi-site observational study with the goal to better understand the natural history and etiology of food allergy by analyzing and integrating data from three complementary study cohorts. Specifically, we hope: 1. To prospectively follow the existent birth cohort at Boston Medical Center (BMC), ~3,000 mother-infant pairs. The Boston birth cohort is well suited for assessing the impact of prenatal and postnatal environment factors, susceptible genes, and cord blood biomarkers in relation to food allergy development and prognosis in childhood. The field data collection procedures are similar to the current CMH IRB protocol # 2004-12324 "BMC Children's Health Study," except that we would like to add (1) additional questions on food allergy in the questionnaire and medical record abstraction; and (2) skin prick test and to measure additional biomarkers related to food allergy. The "BMC Children's Health Study" also has received IRB approval from the Boston University Medical Center. 2. To prospectively follow the existing Chinese twin cohort of about 2000 twin pairs (4,000 subjects) that are 6 years of age and older; Chinese twin cohort offers an ideal tool to estimate heritability (relative role of environmental and genetic factors) of food allergy. The field data collection procedures are similar to the current CMH IRB protocol # 2005-12438 "Epidemiology of Metabolic Syndrome in Children," except that we would like to add (1) additional questions on food allergy in the questionnaire; (2) a skin prick test and to measure additional biomarkers for food allergy. The "Epidemiology of Metabolic Syndrome in Children" also has received IRB approval from the Anhui Medical University in China 3. To establish a prospective clinical cohort at Children's Memorial Hospital, including about 450 nuclear families with at least one child having food allergy (case families) and about 450 control families without any food allergies. The Chicago clinical cohort can serve as an independent population for validating the findings from Boston and Chinese cohorts and lay the foundation for future translational research. The field data collection procedures include: (1) a questionnaire interview; (2) a medical record review; (3) venous blood sample collection and a test of biomarkers for food allergy; (4) a skin prick test; and (5) a pulmonary function test among study subjects aged 6 or older. The unique strength of this study is that it will be conducted as an in-depth cross-sectional and longitudinal investigation on inter-relations and temporal relations among both established and novel food allergy phenotypes and will explore the role of environmental and genetic factors in the development and prognosis of food allergy. This study represents an opportunity to integrate data from three complementary study cohorts. Scientifically, it is ideal to utilize one population for discovery, and to use another for confirmation. These three cohorts together will create a unique and rich database for developing new research initiatives and competing for NIH and other extramural grants.