Brain Correlates of Executive Function during Semantic Retrieval in Schizophrenia

精神分裂症语义检索期间执行功能的大脑相关性

基本信息

  • 批准号:
    7609057
  • 负责人:
  • 金额:
    $ 34.28万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2008
  • 资助国家:
    美国
  • 起止时间:
    2008-04-08 至 2012-02-29
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Both executive functions in working memory (e.g. attention and response inhibition) and semantic functions are known to be compromised in schizophrenia. The former has been associated with general cognitive deficits, while the latter, more specifically with thought disorder and language use in schizophrenia. Currently, an ongoing debate in the literature pits the organization of the semantic system against executive functions as underlying the language disorganization seen in persons with schizophrenia. However, recent behavioral, physiological and imaging evidence suggests that language deficits, specifically thought disorder, are likely to be a result of interactions between executive processes and the semantic system. Accordingly, the long-term objectives of the proposal are to specify the interactions to the extent that they may be used for Identification of a biological and behavioral system useful for the early diagnosis of schizophrenia, as language abnormalities are often one of the first indicators of the disease. The semantic system interacts with executive processes at sensory, phonemic, word, phrase, sentence, and text levels. These interactions increase in complexity and thereby increase cognitive demands as the context moves from words to text levels. The specific aims of this proposal are to evaluate the interaction of executive and semantic processing during manipulations of contextual complexity, and potentially demonstrate both the relationship between behavioral performance during semantic tasks to other measures of semantic processing and the underlying brain system involved. We will specifically examine the effect of executive processes on semantic retrieval and examine the idea that in schizophrenia the failure of fronto-posterior connectivity, with a resulting compensatory increase in fronto- frontal connectivity, are part of language disorganization. This will be done using recently developed behavioral measures of semantic performance and semantic organization, in tandem with functional Magnetic Resonance Imaging and modeling to specify the biological system associated with our results. Healthy volunteers, persons with schizophrenia and their relatives will participate. Our behavioral and modeling results will increase the understanding of the mechanisms underlying semantic deficits in schizophrenia, which is of significant concern in the domain of public health, and has the potential to be an early marker of the disease.
描述(申请人提供):已知精神分裂症患者工作记忆中的执行功能(例如,注意力和反应抑制)和语义功能都受到损害。前者与一般认知缺陷有关,而后者更具体地说与精神分裂症的思维障碍和语言使用有关。目前,文献中正在进行的一场辩论将语义系统的组织与执行功能对立起来,认为这是精神分裂症患者语言混乱的基础。然而,最近的行为、生理和成像证据表明,语言缺陷,特别是思维障碍,很可能是执行过程和语义系统之间相互作用的结果。因此,该提案的长期目标是明确相互作用,以使其可用于识别有助于精神分裂症早期诊断的生物和行为系统,因为语言异常往往是疾病的首批指标之一。语义系统在感觉、音素、词、短语、句子和文本层面上与执行过程相互作用。这些相互作用增加了复杂性,从而增加了认知需求,因为语境从单词移动到文本层面。这一建议的具体目的是评估在语境复杂性操纵过程中执行和语义加工的交互作用,并潜在地证明语义任务中的行为表现与其他语义加工措施和涉及的潜在大脑系统之间的关系。我们将具体研究执行过程对语义提取的影响,并研究精神分裂症患者额后部连接的失败,以及由此导致的额额部连接的补偿性增加,是语言混乱的一部分。这将使用最近开发的语义表现和语义组织的行为测量,结合功能磁共振成像和建模来指定与我们的结果相关的生物系统。健康志愿者、精神分裂症患者及其亲属将参加。我们的行为和建模结果将增加对精神分裂症潜在语义缺陷机制的理解,精神分裂症是公共卫生领域的重要问题,并有可能成为疾病的早期标志。

项目成果

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MALLE ANNE TAGAMETS其他文献

MALLE ANNE TAGAMETS的其他文献

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{{ truncateString('MALLE ANNE TAGAMETS', 18)}}的其他基金

FUNCTIONAL MRI CORRELATES READING, LANGUAGE AND MEMORY
功能性 MRI 将阅读、语言和记忆联系起来
  • 批准号:
    7951144
  • 财政年份:
    2009
  • 资助金额:
    $ 34.28万
  • 项目类别:
Brain Correlates of Executive Function during Semantic Retrieval in Schizophrenia
精神分裂症语义检索期间执行功能的大脑相关性
  • 批准号:
    8016697
  • 财政年份:
    2008
  • 资助金额:
    $ 34.28万
  • 项目类别:
Brain Correlates of Executive Function during Semantic Retrieval in Schizophrenia
精神分裂症语义检索期间执行功能的大脑相关性
  • 批准号:
    7903394
  • 财政年份:
    2008
  • 资助金额:
    $ 34.28万
  • 项目类别:
FMRI CORRELATES READING, LANGUAGE AND MEMORY
FMRI 将阅读、语言和记忆联系起来
  • 批准号:
    7376947
  • 财政年份:
    2006
  • 资助金额:
    $ 34.28万
  • 项目类别:
Visual Plasticity in Schizophrenia:A Training Program
精神分裂症的视觉可塑性:培训计划
  • 批准号:
    7105490
  • 财政年份:
    2002
  • 资助金额:
    $ 34.28万
  • 项目类别:
Visual Plasticity in Schizophrenia:A Training Program
精神分裂症的视觉可塑性:培训计划
  • 批准号:
    6543599
  • 财政年份:
    2002
  • 资助金额:
    $ 34.28万
  • 项目类别:
Visual Plasticity in Schizophrenia:A Training Program
精神分裂症的视觉可塑性:培训计划
  • 批准号:
    6650753
  • 财政年份:
    2002
  • 资助金额:
    $ 34.28万
  • 项目类别:
Visual Plasticity in Schizophrenia:A Training Program
精神分裂症的视觉可塑性:培训计划
  • 批准号:
    6924516
  • 财政年份:
    2002
  • 资助金额:
    $ 34.28万
  • 项目类别:
Visual Plasticity in Schizophrenia:A Training Program
精神分裂症的视觉可塑性:培训计划
  • 批准号:
    6770206
  • 财政年份:
    2002
  • 资助金额:
    $ 34.28万
  • 项目类别:

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