FMRI CORRELATES READING, LANGUAGE AND MEMORY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。精神分裂症是一种以严重的精神扭曲、精神病症状和认知障碍为特征的慢性精神病。然而，精神分裂症的具体机制尚不清楚。人们已经认识到精神分裂症的两个核心缺陷涉及“联想的放松”和语言处理的混乱。虽然语言障碍确实存在，但这些缺陷背后的大脑机制仍未被理解。关于精神分裂症基本语言过程的影像学研究很少。语言是不同认知过程的综合体；本提案的目标是利用这些特性来研究精神分裂症中的语言成分是如何组织的，并找出精神分裂症的基本认知特征如何与特定的脑血流模式和行为测量相关联；如果精神分裂症的模式与正常对照相符。使用功能性核磁共振成像，我们将评估精神分裂症患者和正常志愿者大脑活动模式的变化。这些研究可能会使我们对精神分裂症的发病机制有一些了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Schizophrenia is a chronic psychotic illness characterized by severe mental distortions, psychotic symptoms, and cognitive disturbances. However, the specific mechanism of schizophrenia remains unknown. Two of the core deficits in schizophrenia have been recognized to involve a 'loosening of associations' and disorganization in language processing. While it is clear that language disturbances exist, the brain mechanisms that underlie these deficits are still not understood. There have been few imaging studies of basic linguistic processes in schizophrenia. Language is a complex of associations of different cognitive processes; it is the goal of this proposal to exploit these properties in order to examine how linguistic components are organized in schizophrenia and find out how the basic cognitive characteristics of schizophrenia correlate with specific brain blood flow patterns and behavior measures; and if the patterns of schizophrenia match those in normal controls. Using functional MRI, we will assess changes in brain activity patterns of schizophrenics and normal volunteers. These studies may lead us to some understanding about the mechanism of schizophrenia.