FMRI CORRELATES READING, LANGUAGE AND MEMORY

该子项目是利用NIH/NCRR资助的中心赠款提供的资源的许多研究子项目之一。子项目和研究者（PI）可能从另一个NIH来源获得主要资金，因此可以在其他CRISP条目中表示。所列机构为中心，不一定是研究者所在机构。精神分裂症是一种慢性精神病，以严重的精神扭曲、精神病性症状和认知障碍为特征。然而，精神分裂症的具体机制仍然未知。精神分裂症的两个核心缺陷被认为涉及“联想的松散”和语言处理的混乱。虽然很明显存在语言障碍，但导致这些缺陷的大脑机制仍然不清楚。精神分裂症的基本语言过程的影像学研究很少。语言是一个复杂的协会不同的认知过程，这是本提案的目标，以探讨如何组织在精神分裂症的语言成分，并找出精神分裂症的基本认知特征与特定的脑血流模式和行为措施;如果模式的精神分裂症匹配那些在正常对照组。使用功能性磁共振成像，我们将评估精神分裂症患者和正常志愿者大脑活动模式的变化。这些研究可能会使我们对精神分裂症的发病机制有一些了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Schizophrenia is a chronic psychotic illness characterized by severe mental distortions, psychotic symptoms, and cognitive disturbances. However, the specific mechanism of schizophrenia remains unknown. Two of the core deficits in schizophrenia have been recognized to involve a 'loosening of associations' and disorganization in language processing. While it is clear that language disturbances exist, the brain mechanisms that underlie these deficits are still not understood. There have been few imaging studies of basic linguistic processes in schizophrenia. Language is a complex of associations of different cognitive processes; it is the goal of this proposal to exploit these properties in order to examine how linguistic components are organized in schizophrenia and find out how the basic cognitive characteristics of schizophrenia correlate with specific brain blood flow patterns and behavior measures; and if the patterns of schizophrenia match those in normal controls. Using functional MRI, we will assess changes in brain activity patterns of schizophrenics and normal volunteers. These studies may lead us to some understanding about the mechanism of schizophrenia.