FMRI CORRELATES READING, LANGUAGE AND MEMORY

这个子项目是利用由NIH/NCRR资助的中心拨款提供的资源的许多研究子项目之一。子项目和调查员(PI)可能从另一个NIH来源获得了主要资金，因此可能会出现在其他CRISE条目中。列出的机构是针对中心的，而不一定是针对调查员的机构。精神分裂症是一种以严重的精神扭曲、精神症状和认知障碍为特征的慢性精神疾病。然而，精神分裂症的具体发病机制仍不清楚。精神分裂症的两个核心缺陷被认为与语言处理过程中的“联系松动”和组织紊乱有关。虽然很明显存在语言障碍，但这些缺陷背后的大脑机制仍然不清楚。关于精神分裂症的基本语言过程的成像研究很少。语言是不同认知过程的关联的综合体；这项提议的目标是利用这些特性来研究精神分裂症中语言成分是如何组织的，并找出精神分裂症的基本认知特征如何与特定的脑血流模式和行为测量相关联，以及精神分裂症的模式是否与正常对照组的模式相匹配。使用功能磁共振成像，我们将评估精神分裂症患者和正常志愿者大脑活动模式的变化。这些研究可能会让我们对精神分裂症的发病机制有一些了解。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Schizophrenia is a chronic psychotic illness characterized by severe mental distortions, psychotic symptoms, and cognitive disturbances. However, the specific mechanism of schizophrenia remains unknown. Two of the core deficits in schizophrenia have been recognized to involve a 'loosening of associations' and disorganization in language processing. While it is clear that language disturbances exist, the brain mechanisms that underlie these deficits are still not understood. There have been few imaging studies of basic linguistic processes in schizophrenia. Language is a complex of associations of different cognitive processes; it is the goal of this proposal to exploit these properties in order to examine how linguistic components are organized in schizophrenia and find out how the basic cognitive characteristics of schizophrenia correlate with specific brain blood flow patterns and behavior measures; and if the patterns of schizophrenia match those in normal controls. Using functional MRI, we will assess changes in brain activity patterns of schizophrenics and normal volunteers. These studies may lead us to some understanding about the mechanism of schizophrenia.