Modulation of Cytokine Responses to Improve Transplant Outcome.

骨髓移植仍然是血液系统恶性肿瘤的主要治疗方法。这种疗效是由移植的供者免疫系统介导的，该免疫系统排斥接受者的恶性肿瘤。然而，该过程受到其严重副作用的限制，这种副作用被称为移植物抗宿主病。这一应用寻求在免疫学和临床水平上更好地了解这两个过程，目的是将这两个过程分开，以便更多的患者可以治愈白血病。

Bone marrow transplantation remains a mainstay of curative therapy for haematological malignancies. This curative effect is mediated by the transplanted donor immune system which rejects the recipient malignancy. However, the procedure is limited by its serious side effect, known as graft-versus-host disease. This application seeks to better understand these two processes at both an immunological and clinical level with the aim of separating the two so that more patients may be cured of leukaemia.