NKT cells and Graft-versus-Leukemia Effects

NKT 细胞和移植物抗白血病效应

• 批准号: nhmrc : 389861
• 负责人: Prof Geoff Hill
• 金额: $ 19.96万
• 依托单位: Queensland Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2006
• 资助国家: 澳大利亚
• 起止时间: 2006-01-01 至 2008-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/nkt-cells-graft-leukemia-effects/94956
• 关键词: NKT; cells; Graft; versus; Leukemia

Allogeneic stem cell transplantation (SCT) remains the most effect curative treatment for patients with a number of malignant conditions, especially leukemia. The ability to cure leukemia by this procedure relates to a process known as Graft-versus-Leukaemia effects (GVL) which ocurrs when the newly transplanted stem cells (which includes the immune system) recognises the leukemia as foreign and mounts an immune attack against it. These studies will focus on the effect of a cellular pathway invilving NKT cells that preliminary data suggests is critical to the development of GVL. Methods to augment this activation pathway will be studied in preclinical models that may then be studied in clinical trials with the aim of improving the outcome of patients transplanted for leukemias.

同种异体干细胞移植（SCT）仍然是许多恶性疾病，特别是白血病患者最有效的治疗方法。通过这种方法治愈白血病的能力与一种被称为移植物抗白血病效应（GVL）的过程有关，当新移植的干细胞（包括免疫系统）识别出白血病是外来的，并对其进行免疫攻击时，就会发生移植物抗白血病效应。这些研究将集中在涉及NKT细胞的细胞通路的作用上，初步数据表明，NKT细胞对GVL的发展至关重要。增强这种激活途径的方法将在临床前模型中进行研究，然后在临床试验中进行研究，目的是改善白血病移植患者的预后。