Core 1

核心#1化学博士Wei Wang，Ph.D. 分子成像部门和NTR联盟的化学核心职能是：（i）提供 开发用于核成像和光学成像的新分子靶向实体的能力;（ii）开发 新制剂所需的经验证的分析工具;以及（iii）提供制造方面的协助。 新靶向实体王伟博士的专业知识和展示的创新是显而易见的小动物 关于c（KRGD）和c（KAHWGFLD）双标记成像的成像结果见第5.C.4，5节 剂.以下提供了她与查尔斯·布鲁恩迪博士合作开发一种 用于成像vTK基因表达的光学基底。 [18 F]-FHBG和其他同位素底物已沿着与其他几种TK底物一起使用[143-145]。 虽然[18F]-FHBG目前被批准作为人体研究的研究药物[146]，但其半衰期短， （2 h）可能是小动物成像中高背景的原因。例如，在研究中， 表达vTK的肿瘤细胞，研究者常规使用皮下肿瘤植入在患者的肩部， 动物后一小时 管理， 不完全清除 防止区分 肿瘤细胞在 动物的躯干。在 同位素加成 标记的代理商不 广泛提供给 生物医学研究 社区为此 王伟博士 开发三个光学 FHBG类似物 在图43中描绘， 与NIR结合 IR 783染料是内部合成的。值得注意的是，第二种化合物可以作为一种药物开发。 通过用18 F取代冷氟，潜在的双标记PET和光学成像剂。

Core #1 Chemistry Dr. Wei Wang, Ph.D. The Chemistry core functions in the Division of Molecular Imaging and in this NTR consortium to (i) provide the ability to develop new molecularly targeting entities for both nuclear and optical imaging; (ii) develop the validated analytical tools necessary for new agents; and (iii) provide assistance in manufacture. New targeting entities Dr. Wei Wang's expertise and demonstrated innovation is evident in the small animal imaging results presented in Section 5.C.4,5 regarding the c(KRGD) and c(KAHWGFLD) dual labeled imaging agents. The following provides an example of her emerging work with Dr. Charles Brunicardi to develop an optical substrate for imaging vTK gene expression. [18F]-FHBG and other isotope substrates have been used along with several other TK substrates [143-145]. Although [18F]-FHBG is currently approved as an investigational drug for human studies [146], its short half life (2 h) may be responsible for the high background in small animal imaging. For example, in studies to track vTK expressing tumor cells, investigators routinely use subcutaneous tumor implantation on the shoulder of animals. One hour after administration, incomplete clearance prevents distinguishing tumor cells within the trunk of the animal. In addition, isotopically labeled agents are not widely available to the biomedical research community. For this reason, Dr. Wei Wang developed three optical analogs of FHBG depicted in Fig. 43 that are conjugated to NIR dye IR783 that is synthesized in-house. It is noteworthy that the second compound, could be developed as a potential dual labeled PET and optical imaging agent by replacing cold fluorine with 18F.