Core 1

核心#1化学博士王伟，博士。 分子成像部和这个NTR联盟的化学核心职能：(I)提供 开发用于核和光学成像的新的分子靶向实体的能力；(2)开发 新试剂所需的经过验证的分析工具；以及(Iii)在制造过程中提供协助。 新的目标实体王伟博士的专业知识和展示的创新在小动物中是显而易见的 关于c(KRGD)和c(KAHWGFLD)双标记成像的成像结果在第5.C.4，5节中给出 探员们。以下是她与查尔斯·布鲁尼卡迪博士正在进行的合作的一个例子 VTK基因表达成像的光学底物。 [18F]-FHBG和其他同位素底物与其他几种TK底物一起使用[143-145]。 虽然[18F]-FHBG目前被批准作为人体研究的研究药物[146]，但它的半衰期很短 (2 H)可能是小动物成像本底偏高的原因。例如，在跟踪研究中 VTK表达的肿瘤细胞，研究人员常规使用皮下种植肿瘤在肩部 动物。一小时后 行政管理， 不完全间隙 阻止区分 体内的肿瘤细胞 动物的躯干。在……里面 加法，同位素 已标记的座席会 广泛提供给 生物医学研究 社区。为了这个 原因，王伟博士 开发了三个光纤 FHBG的类似物 如图43所示， 与近红外光谱结合 内部合成的染料IR783。值得注意的是，第二种化合物可以作为一种 潜在的双标记PET和光学显像剂，用18F取代冷氟。

Core #1 Chemistry Dr. Wei Wang, Ph.D. The Chemistry core functions in the Division of Molecular Imaging and in this NTR consortium to (i) provide the ability to develop new molecularly targeting entities for both nuclear and optical imaging; (ii) develop the validated analytical tools necessary for new agents; and (iii) provide assistance in manufacture. New targeting entities Dr. Wei Wang's expertise and demonstrated innovation is evident in the small animal imaging results presented in Section 5.C.4,5 regarding the c(KRGD) and c(KAHWGFLD) dual labeled imaging agents. The following provides an example of her emerging work with Dr. Charles Brunicardi to develop an optical substrate for imaging vTK gene expression. [18F]-FHBG and other isotope substrates have been used along with several other TK substrates [143-145]. Although [18F]-FHBG is currently approved as an investigational drug for human studies [146], its short half life (2 h) may be responsible for the high background in small animal imaging. For example, in studies to track vTK expressing tumor cells, investigators routinely use subcutaneous tumor implantation on the shoulder of animals. One hour after administration, incomplete clearance prevents distinguishing tumor cells within the trunk of the animal. In addition, isotopically labeled agents are not widely available to the biomedical research community. For this reason, Dr. Wei Wang developed three optical analogs of FHBG depicted in Fig. 43 that are conjugated to NIR dye IR783 that is synthesized in-house. It is noteworthy that the second compound, could be developed as a potential dual labeled PET and optical imaging agent by replacing cold fluorine with 18F.