AIRWAY AND IMMUNE RESPONSE TO INHALED ENDOTOXIN AND DIESEL EXHAUST PARTICLES

对吸入内毒素和柴油机尾气颗粒的气道和免疫反应

• 批准号: 7604874
• 负责人: Thomas Michael Peters
• 金额: $ 0.57万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604874
• 关键词: Affect; Air; Asthma; Bacteria; Breathing; Computer Retrieval of Information on Scientific Projects Database; Diesel Exhaust; Dust; Endotoxins; Environment; Exposure to; Farming environment; Funding; Grant; Health; Immune response; Institution; Learning; Lung; Persons; Purpose; Research; Research Personnel; Resources; Source; Symptoms; Time; United States National Institutes of Health; airway inflammation; farm worker; particle; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of this research study is to evaluate potential interactions between diesel exhaust particles (DEP) and endotoxin on airway function. Endotoxin is made by bacteria in the environment. It is present in most of the air that we breathe, and is found in higher concentrations in dust from farms. Inhaling endotoxin has been shown to cause symptoms similar to asthma, and we are investigating whether endotoxin exposure at the same time as exposure to diesel exhaust particles leads to more inflammation of the airway. By learning about how DEP and endotoxin affect the lungs, we hope to gain a better understanding of the health problems of farm workers as well as persons with asthma.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 本研究的目的是评估柴油机尾气颗粒 (DEP) 和内毒素之间对气道功能的潜在相互作用。 内毒素是由环境中的细菌产生的。 它存在于我们呼吸的大部分空气中，并且在农场灰尘中含量较高。 吸入内毒素已被证明会引起类似于哮喘的症状，我们正在研究在接触柴油机尾气颗粒的同时接触内毒素是否会导致更多的气道炎症。 通过了解 DEP 和内毒素如何影响肺部，我们希望更好地了解农场工人和哮喘患者的健康问题。