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Methods to Assess Personal Exposures to Airborne Metallic Nanoparticles

评估个人接触空气中金属纳米颗粒的方法

基本信息

批准号：
8131776
负责人：
Thomas Michael Peters
金额：
$ 21.38万
依托单位：
UNIVERSITY OF IOWA
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2013-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8131776
关键词：
Methods Assess Personal Exposures Airborne

项目摘要

DESCRIPTION (provided by applicant): When inhaled, nanoparticles can elicit adverse cardiopulmonary health outcomes and their toxicity, particularly for metals and metal oxides, can be substantially greater than that of larger particles of the same composition. No standard measurement methods are available to quantitatively assess personal exposures to engineered nanoparticles, and without such methods, the extent to which workers are at risk from inhalation of nanoparticles is unknown. The laboratory work proposed in this research plan will standardize and validate measurement methods needed to quantify personal exposure to a range of metallic nanoparticles that are commonly incorporated into commercial products. We will develop an innovative nanoparticle deposition (NPD) sampler to collect nanoparticles specifically (separate from the larger particles in workplace air) and in a manner that reflects their deposition in the respiratory tract (Aim 1). We will also develop and validate a method to analyze the content of metal in the nanoparticles collected with the NPD sampler (Aim 2). These sampling and analysis methods will be easily adaptable by industrial hygiene practitioners to provide the system needed to assess worker exposure to metal nanoparticles. They will also represent enabling tools to study potential epidemiological relationships among metallic nanoparticle exposures and adverse acute health effects. PUBLIC HEALTH RELEVANCE: This work will result in methodologies to measure personal exposure to airborne metal and metal-oxide nanoparticles. As such it is applicable to assessing worker exposures to engineered nanomaterials in the burgeoning field of nanotechnology.

描述（由申请人提供）：当吸入时，纳米颗粒可引起不利的心肺健康结果，并且其毒性，特别是对于金属和金属氧化物，可显著大于相同组成的较大颗粒。没有标准的测量方法可用于定量评估工程纳米颗粒的个人暴露，如果没有这样的方法，工人吸入纳米颗粒的风险程度是未知的。本研究计划中提出的实验室工作将标准化和验证量化个人暴露于一系列金属纳米颗粒所需的测量方法，这些金属纳米颗粒通常被纳入商业产品中。我们将开发一种创新的纳米颗粒沉积（NPD）采样器，专门收集纳米颗粒（与工作场所空气中的较大颗粒分离），并以反映其在呼吸道中沉积的方式（目标1）。我们还将开发和验证一种方法来分析NPD采样器收集的纳米颗粒中的金属含量（目标2）。这些采样和分析方法将很容易被工业卫生从业人员调整，以提供评估工人接触金属纳米颗粒所需的系统。它们还将成为研究金属纳米颗粒暴露与不良急性健康影响之间潜在流行病学关系的有利工具。公共卫生相关性：这项工作将产生测量个人暴露于空气中金属和金属氧化物纳米颗粒的方法。因此，它适用于评估工人暴露于新兴的纳米技术领域的工程纳米材料。