INFLUENCE OF CARDIOVASCULAR FITNESS IN PARKINSON'S DISEASE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 帕金森氏病(PD)患者除了典型的运动功能障碍外，甚至在疾病的早期阶段也会遭受广泛的认知异常，特别是执行功能障碍。横向和纵向研究表明，久坐不动的健康老年人心血管健康程度的适度提高，可能是通过增加IGF-1等营养因子来改善大脑的可塑性，从而减少与衰老有关的执行功能的下降。动物模型和流行病学研究表明，有氧运动可能对帕金森病具有神经保护作用。然而，在帕金森病患者中，关于有氧运动计划或有氧耐力状态对疾病的运动和认知方面的影响的实验信息非常有限。 这些研究人员将进行一项关于心血管健康对帕金森病患者执行和运动功能的影响的横断面研究。他们将通过自行车测功机上的有氧耐力评估来评估20名55-75岁的轻中度(Hoehn-Yahr阶段I-III)PD患者的健康水平，这些患者独立生活，可以在没有帮助的情况下行走。他们将通过自行车功率机运动测试中最大摄氧量(VO2)的中位数分裂将受试者分为低适应组和高适应组。他们将比较低适合度PD组和高适合度PD组在执行、其他认知和运动功能测试中的表现，并根据年龄、性别和病程进行调整。有氧健身水平(VO2)与执行和运动功能之间的相关性分析也将被进行。一个亚组(n=10)还将接受脑功能和形态计量学研究，以及CRP、IL-6和IGF-1(炎症和营养反应的指标)的水平。这项研究的MRI部分将在UIHC的PD患者中建立这些方法，意识到这个小样本可能足以显示任何显著的相关性或组内差异。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Patients with Parkinson's disease (PD), in addition to typical motor dysfunction, also suffer from a wide spectrum of cognitive abnormalities, especially executive dysfunction, even in the early stages of the disease. Cross-sectional and longitudinal studies have shown that modest increases in cardiovascular fitness in sedentary healthy elderly reduce aging-related decline in executive functions, possibly by improving plasticity of the brain, mediated by the increase in trophic factors such as IGF-1. Animal models and epidemiologic studies suggest that aerobic exercise may have a neuroprotective effect on PD. However, there is very limited experimental information in patients with PD on the effect of aerobic exercise programs or aerobic endurance status on motor and cognitive aspects of disease. These investigators will conduct a cross-sectional study on the effect of cardiovascular fitness on executive and motor functions in PD. They will assess the fitness level by aerobic endurance capacity assessment on a cycle ergometer in 20 mild-moderate (Hoehn-Yahr stages I-III) PD patients aged 55-75 who are living independently and can ambulate without assistance. They will separate the group into low-fit and high-fit by a median split on their maximal oxygen uptake (VO2) during the cycle ergometer exercise test. They will compare the performance of the low- and high-fit PD groups on executive, other cognitive and motor function tests adjusting for age, gender and disease duration. Correlational analyses between aerobic fitness level (VO2) and executive and motor functions will also be performed. A subgroup (n=10) will also undergo functional and morphometric brain MRI studies, and levels of CRP, IL-6, and IGF-1 (indicators of inflammation and trophic response). The MRI part of the study will be performed to establish these methods at the UIHC in patients with PD, realizing that this small sample may be enough to show any significant correlations or group differences.