SLEEP AND PCOS

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol has three Specific Aims: 1. to test the hypothesis that sleep disturbances are caused by the hormonal alterations (specifically hyperandrogenemia and hyperinsulinemia) that characterize women with PCOS; 2. to test the hypothesis that sleep disturbances cause the hormonal, metabolic and cardiovascular alterations seen in women with PCOS; 3. to test the hypothesis that in normal young women, experimental manipulations of sleep that partially recapitulate the sleep disturbances characteristic of women with PCOS will result in metabolic, hormonal, and cardiovascular alterations that are typical of the metabolic syndrome.