A RANDOMIZED, PLACEBO-CONTROLLED PILOT STUDY IN HUNTINGTON'S DISEASE (CIT-HD)

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This research plan proposes to conduct a double-blind, placebo-controlled pilot clinical trial in 20 adults with mild Huntington's Disease (HD) to address the following research aims: 1) To determine the effect of citalopram compared to placebo in patients with early HD on executive function and other outcome variables, including functional measures (health-related quality of life, work productivity, and self-reported attention), motor performance, and psychiatric status, 2) To study the relationship between executive function and functional status in patients with early HD after SSRI treatment and 3) to examine the effect of citalopram treatment on volumetric and metabolic (i.e., N-Acetyl-Aspartate concentrations) in the neostriatum among patients with recently diagnosed Huntington's Disease.