PROSPECTIVE LUPUS COHORT STUDY OF DISEASE ACTIVITY AND PREDICTORS OF MORBIDITY

疾病活动性和发病预测因素的前瞻性狼疮队列研究

• 批准号: 7604532
• 负责人: MICHELLE A PETRI
• 金额: $ 9.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604532
• 关键词: Address; Adrenal Cortex Hormones; Adverse effects; Antiphospholipid Antibodies; Blood; Clinical Research; Coagulation Process; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Disease; Early treatment; Fibromyalgia; First Independent Research Support and Transition Awards; Funding; Future; Grant; Institution; Lupus; Morbidity - disease rate; Muscle; Numbers; Organ; Patients; Prednisone; Questionnaires; Research; Research Personnel; Resources; Risk; Risk Factors; Schedule; Source; Systemic Lupus Erythematosus; Testing; Thrombosis; Time; United States National Institutes of Health; Visit; Work; cardiovascular risk factor; cohort; disability; follow-up; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Lupus Center at JHH is uniquely situated to address clinical research issues through prospective follow-up of a large number of SLE patients. During Dr. Petri's FIRST award, issues addressed included the risk of future thrombosis and coronary artery disease associated with antiphospholipid antibodies, routine cardiovascular risk factors, and prednisone use. The Lupus Cohort has now been refunded by the NIH. The specific aims of the RO-1, although a continuation of the FIRST award work, now include an emphasis on disease activity and disability. Ongoing disease activity exposes patients to the side effects of corticosteroids. Over one-half of patients sustain permanent organ damage. Determination of predictors of disease activity should help to reduce unneeded corticosteroid treatment and allow institution of earlier treatment when it is needed. Whenever a patient has a scheduled visit, three to ten extra tablespoons of blood are drawn to test for disease activity and clotting. A record of tender muscles (fibromyalgia) is also completed. In addition, several times a year, patients are contacted so that we can determine other risk factors for organ damage and disability (through the use of questionnaires).

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