PROSPECTIVE LUPUS COHORT STUDY OF DISEASE ACTIVITY AND PREDICTORS OF MORBIDITY

疾病活动性和发病预测因素的前瞻性狼疮队列研究

• 批准号: 7604532
• 负责人: MICHELLE A PETRI
• 金额: $ 9.43万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-12-01 至 2007-09-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7604532
• 关键词: Address; Adrenal Cortex Hormones; Adverse effects; Antiphospholipid Antibodies; Blood; Clinical Research; Coagulation Process; Cohort Studies; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Disease; Early treatment; Fibromyalgia; First Independent Research Support and Transition Awards; Funding; Future; Grant; Institution; Lupus; Morbidity - disease rate; Muscle; Numbers; Organ; Patients; Prednisone; Questionnaires; Research; Research Personnel; Resources; Risk; Risk Factors; Schedule; Source; Systemic Lupus Erythematosus; Testing; Thrombosis; Time; United States National Institutes of Health; Visit; Work; cardiovascular risk factor; cohort; disability; follow-up; prospective

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Lupus Center at JHH is uniquely situated to address clinical research issues through prospective follow-up of a large number of SLE patients. During Dr. Petri's FIRST award, issues addressed included the risk of future thrombosis and coronary artery disease associated with antiphospholipid antibodies, routine cardiovascular risk factors, and prednisone use. The Lupus Cohort has now been refunded by the NIH. The specific aims of the RO-1, although a continuation of the FIRST award work, now include an emphasis on disease activity and disability. Ongoing disease activity exposes patients to the side effects of corticosteroids. Over one-half of patients sustain permanent organ damage. Determination of predictors of disease activity should help to reduce unneeded corticosteroid treatment and allow institution of earlier treatment when it is needed. Whenever a patient has a scheduled visit, three to ten extra tablespoons of blood are drawn to test for disease activity and clotting. A record of tender muscles (fibromyalgia) is also completed. In addition, several times a year, patients are contacted so that we can determine other risk factors for organ damage and disability (through the use of questionnaires).

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 JHH 的狼疮中心具有独特的优势，可以通过对大量 SLE 患者进行前瞻性随访来解决临床研究问题。在 Petri 博士获得 FIRST 奖项期间，解决的问题包括与抗磷脂抗体相关的未来血栓形成和冠状动脉疾病的风险、常规心血管危险因素和泼​​尼松的使用。狼疮队列现已获得美国国立卫生研究院 (NIH) 的退款。 RO-1 的具体目标虽然是 FIRST 奖项工作的延续，但现在包括强调疾病活动和残疾。持续的疾病活动使患者面临皮质类固醇的副作用。超过一半的患者遭受永久性器官损伤。确定疾病活动的预测因子应有助于减少不必要的皮质类固醇治疗，并允许在需要时进行早期治疗。 每当患者预约就诊时，都会额外抽取三到十汤匙血液来测试疾病活动性和凝血情况。肌肉压痛（纤维肌痛）的记录也已完成。此外，我们每年都会多次联系患者，以便我们能够确定器官损伤和残疾的其他风险因素（通过使用调查问卷）。